Handbook of the Biology of Aging

ISBN-13: 9780128159620 / Angielski / Miękka / 2021 / 468 str.

Nicolas Musi; Peter Hornsby

Spis treści

Part I: Basic mechanisms, underlying physiological changes, model organisms and interventions

1. Longevity as a complex genetic trait

2. DNA damage and repair in aging

3. Mechanisms of cell senescence in aging

4. The nature of aging and the geroscience hypothesis

5. Sirtuins, healthspan, and longevity in mammals

6. Integrative genomics of aging

7. Thermogenesis and aging

8. Yeast as a model organism for aging research

9. Model organisms (invertebrates)

10. NIA Interventions Testing Program: A collaborative approach for investigating interventions to promote healthy aging

11. Aging in nonhuman primates

Part II: Organ systems in humans and other animals, human health and longevity

12. Senotherapeutics: Experimental therapy of cellular senescence

13. The role of neurosensory systems in the modulation of aging

14. Aging of the sensory systems: hearing and vision disorders

15. Cardiac aging

16. The aging immune system: Dysregulation, compensatory mechanisms, and prospects for intervention

17. Microbiome changes in aging

18. Lipidomics of aging

19. Trends in morbidity, healthy life expectancy, and the compression of morbidity