Handbook of Pharmaceutical Granulation Technology: Fourth Edition

ISBN-13: 9780367334772 / Angielski / Twarda / 2021 / 904 str.

Dilip M. Parikh

Opis

This fully revised edition covers the rapid advances in the science of agglomeration,  process control, process modelling, scale-up, emerging particle engineering technologies, along with current regulatory changes presented by some of the prominent scientist and subject matter experts around the globe. 

Spis treści

1 Introduction  2 Theory of Granulation: An Engineering Perspective  3 Drug Substance and Excipient Characterization  4 Binders in Pharmaceutical Granulation  5 Excipients and their Attributes in Granulation  6 Spray Drying and Pharmaceutical Applications  7 Emerging Technologies for Particle Engineering  8 Roller Compaction Technology  9 Advances in Wet Granulation of Modern Drugs  10 Fluid Bed Granulation  11 Single Pot Processing  12 Extrusion/Spheronization as a Granulation Technique  13 Continuous Granulation  14 Effervescent Granulation  15 Granulation of Plant Products and Nutraceuticals  16 Granulation Approaches for Modified Release Products  17 Granulation of Poorly Water-Soluble Drugs  18 Granulation and Production Approaches of Orally Disintegrating Tablets  19 Melt Granulation  20 Sizing of Granulation  21 Granulation Characterization  22 Bioavailability and Granule Properties  23 Granulation Process Modeling  24 Scale-Up Considerations in Granulation  25 Advances in Process Controls and End-Point Determination  26 Use of Artificial Intelligence and Expert Systems in Pharmaceutical Applications  27 Regulatory Issues in Granulation: Leading Next Generation Manufacturing

O autorze

Dilip M. Parikh is President, DPharma Group Inc., Ellicott City, Maryland, USA. As a Chemical and pharmaceutical engineer, he has more than 45 years of experience in product developments and manufacturing, process engineering, operational management of various pharmaceutical facilities in Canada and the USA. He is an invited speaker globally on various solid dosage manufacturing technologies and troubleshooting, process optimization strategies, regulatory remediation, and PAT & QbD implementation strategies. The author of many scientific journal articles, book chapters, and the editor of first, the second and third edition of Handbook of Pharmaceutical Granulation Technology.