Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

ISBN-13: 9789811594106 / Angielski / Twarda / 2022 / 2575 str.

Sajal Chakraborti; Bimal K. Ray; Sushanta Roychowdhury

Spis treści

Involvement of ROS in thyroid cancer

Skin cancer induced by pollution-medicated ROS

Roles of β-Glucans in Oxidative Stress and Cancer

Oxidative stress in glioma and its microenvironment

Reactive oxygen species and their contribution to carcinogenesis

Oral cancer and oxidative stress

Oxidative stress in genitourinary cancer

Oxidative stress in oral cancer

Oxidative stress and glyoxalase pathway in cancer

ROS and EMT in multistep carcinogenesis

Functional regulation between matrix metalloproteases and cell junction proteins in gastric cancer

Association of oxidative stress and mitochondrial dysfunction to gynaecological malignancies

Impact of Caenorhabdits elegans in cancdeer drug resistance and development

Pharmacology of natural products specifically plant based mitigating cisplatin-induced cardiotoxicity and attenuating oxidative stress, inflammation and associated signalling pathways

Scafold based selective ROS generation as viable therapeutic strategies

Opportunity for natural and synthetic compounds and stem cell therapy

Targeting ROS/RNS for Gliobastoma multiforme treatment strategy

Targeting mitochondria as a novel disease modifying therapeutic strategy in Cancer

Oxidative stress and cancer: Impact of Yoga and its prevention

Cutaneous Oxidative Stress Mediated Endoplasmic Reticulum (ER) Stress and Unfolded Protein Responses (UPR)

Iron sulfer clusters and ROS in cancer

Biomarkers of Oxidative Stress

Identification of oxidative stress targets in cancer

Role of apoptotic biomarkars during oxidative stress and cancer

Biomarkers of Oxidative Stress and its dynamics in cancer

Glutathione as Oxidative stress marker in Cancer

Salivary oxidative stress biomarkers in oral potentially malignant disorders and sqamous cell carcinoma

Recent Development of Monoclonal Antibodies targeting tyrosine kinase in ROS mediated Cancer

Fluoride induced oxidative stress and cancer

Role of ROS in chemical carcinogenesis induced by cadmium, lead, chromium and nickel

Environmental contaminants and the risk of reproductive cancers

Environmental pollutants, oxidative stress and organismal health: Household of three

Environmental and occupational contaminants in cancer development

Benzo(a)pyrine induced ROS- mediated lung cancer

Essential role of occupational hazards in cancer among women

New insights on ROS-mediated cellular pathways in solid tumors driven by environmental and occupational carcinogenesis

Role of environmental and occupational toxicant in ROS generation and metabolic reprogramming in cancer

Apoptosis in cancer cells

The Impact of Mitochondrial Fission-Stimulated ROS Production on Pro-Apoptotic Chemotherapy

Role of ROS in triggering death receptor-mediated apoptosis

Advanced glycation end products mediated oxidative stress and regulated cell death signalling in cancer

Helping leukemia cell to die with natural and chemical agents through H2O2signaling

Microtube targeting agents induced ROS –mediated apoptosis in cancer

ROS induced by chemo and targeted therapy promote apoptosis in cancer cell

ROS in apoptosis of cancer cells

Induction of apoptosis via Rod signalling pathway

Genomic Instability in Carcinogenesis

Impact of Environmental and Occupational Exposures in ROS Induced Pancreatic Cancer

Reactive oxygen species, central mediators of tumor microenvironment

Current trends in biomarkers of oxidative stress induced cancer

Reactive Oxygen Species in Male Reproductive Cancers

Biomarkers of Oxidative Stress in Cancer, and their Clinical Implications

Biofluid markers unveiling cancer diagnosis and prognosis-with special reference to oxidative stress

The role of reactive oxygen species on cellular fate/function of tumor infiltrating lymphocytes 

ROS mediated inflammatory response in cancer

Food colors and associated oxidative stress in chemical carcinogenesis

Benzo(a)pyrene-induced oxidative stress during lung cancer and treatment with baicalein

Role of oxidative stress in orchestrating genomic instability-associated cancer progression

Hypoxic stress perturb DNA repair mechanisms leading to genetic instability

DNA lesions induced by lipid peroxidation products in cancer progression

Understanding ROS induced DNA damage for therapeutics

Role of Heavy metals in DNA Damage and Cancer Progression

Genotoxicity of ROS induced cancer: Role of natural products

Mitochondria metabolism, oxidative stress and the microenvironment in breast cancer development and progression

Role of oxidative stress and DNA damage/repair pathways in lung cancer

Potential applications of Nrf2 modulators in cancer therapy

Relationship between oxidative stress and immune response in cancer

Oxidative Stress and Cancer: Role of the Nrf2-Antioxidant Response Element Signaling Pathway

Role of Macrophages in Oxidative Stress Induced Inflammatory Tumor Microenvironment

The triad,Hypoxia-ROS –Inflammation

DNA Damage Response and Oxidative Stress

ROS at the intersection of inflammation and immunity in cancer

Sestrin 2 connects Autophagy – Gate keepers against tumor progression

Insights into the role of cadmium in varcinogenesis via modulating Nrf2 pathway

Circadiuacontrol of Nrf2 and SOD1: The nexus of ROS regulation in cancer chronotherapy

Chronic inflammation and oxidative stress due to Helicobacter pylori infection contributes to the genesis and perpetuation of gastric cancer

New insights into the oxidative stress-induced immune pathogenesis of ovarian cancer

Oxidative dyshomeostasis in the mitochondria

Role of ROS in tumor progression

ROS in cancer metastasis

The interdependence of inflammation and ROS in cancer

Interplay between oxidative stress and endoplasmic reticulum stress in the metastasis of colon cancer

Mitochondria-targeted antioxidants and cancer

ROS-mediated genome alterations at cellular microenvironment during cancer metastasis

Role of oxidative stress mediated-microRNA alterations in ovarian cancer progression and metastasis

Oxidative stress in cancer and its influence on amoeboidal migration

Intricacy of ROS in cancer therapy resistance

Hypoxia and Oxidative Stress in Progression of  Breast Cancer

Effect of  oxidative stress on autophagy

TRP channels, oxidative stress and cancer

Wnt signaling in cancer

Two-faced role of ROS in the regulation of cancer cell signalling

Oxidative Stress and Notch Signaling

ROS induced regulatory cross-talk with autoiphagy and Akt

Redox regulation of estrogen signalling in human breast cancer

ROS impacts on cell cycle checkpoint signalling in carcinogenesis

Phosphoinositide -3-kinase/Akt signalling and oxidative stress in cancer

Modulation of JAK/STAT Pathways in Cancer by Phytochemicals

P62/SQSTM1 –Keap1-Nrf2 pathway – Key regulators in lung cancer

ROS-mediated MAP kinase dependent signalling pathway in tumor progression

Role of carotenoids on oxidative stress-mediated signaling in cancer cells

Cross-talk between oxidative stress and p53 family members in regulating cancer

Impact of oxidative stress induced signal transduction in the tumor micro-environment and cancer development.

Mutant K-ras mediated oxidative stress in pancreatic cancer

Oxidative stress and antioxidant enzymes-coding genes expression in cancer cell models.

Regulation of the expression of voltage gated anion channels by noncoding RNA in cancer metastasis

mRNA stabilizing factors, new players in cancer progression

Redox state and gene regulation in breast cancer

Role of a novel ROS generating gene in Uveal Melanoma

Administration of siRNA  to the targeted site of action in cancer research

Role of cigarette smoke in oxidant induced lung cancer

Oxidantinduced gene regulation in gastriccancer

Oxidative stress induced gene regulation in pancreatic cancer

Epigenetic therapy as a potential approach for targeting oxidative stress induced Non small cell lung cancer

Free radicals mediated epigenetic changes and breast cancer progression

Phytochemicals in ROS-mediated epigenetic regulation of cancer

ROS effects on telopmere in cancer

Interplay between ROS, noncoding RNAs and cancer

Noncoding regulation of redox balance in cancer

Epigenetic regulation of micro RNA expression in cancer

Oxidized DNA base damage repair and transcription

Epigenetic instability caused by oxidative stress can trigger tumorigenesis

Oxidative stress and cancer stem cells

Metabolims - redox status interplay in tumor stem cells signaling

Association of ROS with epithelial-mesenchymal transition and acquisition of stemness during carcinogenesis

Therapeutic effect of molecules in targeting ROS induced cancer

Therapeutics of Oxidative Stress and Stemness in Breast Cancer

Effect of ROS signalling on stem cells

Targeting redox signalling and ROS metabolism in cancer treatment

Modulatory role of adipocytes and their stem nature in the ROS signalling within a tumor microenvironment

Hypoxia induced stress responses in cancer and cancer stem cells

Oxidative stress targeted therapies for treatment of leukemia

Role of ROS in cancer stem cells: Avenues of interventional therapy

Reactive oxygen species dependent signalling pathways in cancer stem cells: Implications in resistance to therapy

System Biology and Network Analysis approaches on oxidative stress in cancer

Reactive Oxygen Species Mediated Cancer Progression and Metastasis

Role of Metabolic Reprogramming in ROS induced anti cancer therapeutics?

Na,K-ATPase natural and synthetic inhibitors as anticancer drugs

Anthrocyanins and Flavonols

Implication of nanomedicine in therapy of oxidative stress induced cancer

Metabolic oxidative stress in initiation, progression and therapy of cancer

Mitochondrial ROS

Oxidative stress and hypoxia in cancer - implications for radiation therapy

Oxidative stress in cancer

Phytocompounds based approaches

Phytoestrogens modulate oxidative stress

Prospective applications of natural and synthetic redox modulators in oxidative stress-targeted cancer therapy

ROS modulation by iron chelators and synthetic lipids---- a developing anti-cancer strategy

ROS, cancer and stem cells

Restortive ramnifications of flavonoids and their comjugates in ROS induced cancer

Small Molecule Modulators of ROS/NF-κBSignaling in Cancer Therapy

Targeting hyperglycolysis---oxidative stress apoptosis and by natural ans synthetic compounds in hepatocellulau carcinoma

Association of sugary drinks and risk of cancer

Bioinformatics application in evaluation of reactive oxidative stress (ROS) and discover patterns in anti-oxidative stress response (AOS)

Constraint based reconstruction and analysis for ROS-mediated effects in colon cancer

Dynamical methods to study interaction in proteins facilitating molecular understanding of cancer

E3 ubiquitin ligases in cancer

Insulin resistance and cancer

Meprins

Molecular analysis of the involvement of IncRNA in cancer development

Omics' approach to oxidative stress and cancer:

Proteomics and metabolomics in cancer diagnosis and therapy

Reactive Oxygen Species induced cancer

Systems biology and bioinformatic insights into the role of free radical-mediated oxidative damage in the pathophysiology of cancer

Systems biology tools and their clinical applications in cancer therapy

The yin and yang of ROS homeostasis and metabolism in cancer

Thioredoxin and Glutathione

Vitamin C in cancer management: clinical evidence and involvement of redox role

Oxidative Stress, Inflammasome and Cancer

Preventive role of carotenoids in  oxidative stress induced cancer

Personalized vaccine as a therapeutic approach towards Cancer

Oxidative stress and nutritional status in cancer

Enolase: a factor common to cancers and stem cells, yet with divergent function in response to ROS

Analytical and omics approaches in the identification of oxidative stress-induced cancer biomarkers

Role of ROS in cancer stem cell  tumorigenesis, metastasis, and treatment resistance 

Dynamics of Cobalt Oxide Nanoparticles in activation of ROS linked inflammation and immunomodulation

Cancer chemopreventive properties of gallic acid involves mobilization of copper levels and reactive oxygen species generation

Nitrogen- and sulfur-containing heterocycles as dual anti-oxidant and anti-cancer agents

O autorze

Dr. Sajal Chakraborti is a Professor of Biochemistry in the University of Kalyani, West Bengal, India. His research covers the role of oxidant –mediated signalling in the pathogenesis of a variety of diseases. Prof. Chakraborti did is PhD from Calcutta University (1982) and D.Sc from Kalyani University (2004). He did post doctoral research at the Johns Hopkins University, Baltimore; University of Utah Health Sciences Center, Salt Lake City and New York Medical College, New York as a Fulbright Fellow. He received DBT (Govt. of India)-senior overseas research award for his research at the University of Florida, Gainesville (1998-1999). He has been engaged in teaching and research in biochemistry for the past 40 years. He has published over 110 original research papers, 22 book chapters and 15 review articles. He also edited 12 books (Springer).

Dr. Bimal K Ray is a Professor of Pathology of the University of Missouri, Columbia, Missouri, USA. He has more than 40 years of teaching and research experience in different universities in USA. One of his research interests is the understanding the basic mechanisms associated with inflammation, the consequence of which is linked to abnormal gene expression that may lead to cancer. Recent findings of Dr. Ray’s laboratory suggest that serum amyloid A-activating factor-1 (SAF-1) activates superoxide dismutase and few other reactive species sensitive antioxidant enzymes in breast cancer and thereby allowing cancer cell proliferation. Dr. Ray published over 100 original research papers and review articles in different international journals of repute. He also published several chapters in books published by reputed publishers.

Dr. Susanta Roychoudhury obtained his Ph.D degree from Calcutta University in 1985. He did postdoctoral research at the University of Pennsylvania, USA (1985 to 1990). After that he joined the CSIR-Indian Institute of Chemical Biology, Kolkata, India as a scientist (1991-2015). Subsequently, he was associated with Saroj Gupta Cancer Centre & Research Institute, Kolkata, India as Chief of Basic Research (2015-2021). Currently, he is the ICMR Emeritus Scientist at CSIR-Indian Institute of Chemical Biology, Kolkata, India. As a cancer geneticist, Dr. Roychoudhury made significant contributions on the molecular understanding of the genomic instabilities and functional consequences of gain-of function mutations of TP53 gene in human cancer. He has contributed in the area of cancer stem cells using oral cancer model and developed a microarray-based gene expression signature that distinguishes the aggressive subset of early stage oral cancer from non-aggressive one. He has published over 150 original research articles in several international journals of repute and several review articles and book chapters. Dr. Roychoudhury is the Fellow of all the three Science Academies of India. He has been elected as President of Indian Association for Cancer Research in 2016 and is a recipient of Sir J C Bose National Fellowship by Department of Science and Technology, Govt. of India in 2017.