Handbook of Oncobiology: From Basic to Clinical Sciences

ISBN-13: 9789819962624 / Angielski

R. C. Sobti; Nirmal K. Ganguly; Rakesh Kumar

Spis treści

1. Current Concepts and Advances in Oncobiology
2. History, Evolution, Milestones in Cancer Research and Treatment
3. Cancer Statistics: Geographical and Racial Disparities
4. A Comprehensive Overview of Various Cancer Types and Their Progression
5. Strategies of Early Diagnosis of Cancers
6. Advancement in Cancer Modeling System: Latest Developments and Trends in Cancer Research and Healthcare Interventions
7. Point of Care Molecular Diagnostics in Cancer
8. Genetics of Cancer: Past, Present and Future
9. Mechanisms of Oncogenesis
10. Recent Developments in Cancer Detection and Treatment
11. Circadian Rhythms and Their Association with Cancer Development
12. Advances in Cancer Pain Management
13. Genetic Alterations and Microbial Dysbiosis Underlie Lymph Node Metastasis in Tongue Cancer
14. Skin Cancer: An Overview
15. Squamous Cell Carcinoma Predisposition Pathophysiology, Diagnosis, and Treatment
16. Tumor Heterogeneity in Breast Cancer Progression
17. Molecular Pathways in Breast Cancer Chemoresistance
18. Therapeutic Efficacy of Estrogen Related Receptor β in Breast Carcinoma
19. Diagnostic-Prognostic Biomarkers and Their Clinical Implication in Breast Cancer
20. Tumour Inflammatory Microenvironment in Lung Cancer: Heterogeneity and Implications
21. Brain Tumors: Types, Diagnostic Biomarkers and New Therapeutic Approaches
22. Current Pathophysiology, Treatment, and Future Perspective for Prostate Cancer
23. Emerging Pathophysiology and Treatment Prostate Cancer: Future Perspective
24. Androgen Receptor Signaling: a Central and Evolving Theme in Prostate Cancer Treatment
25. Structuring Inflammasome-Epigenome – Phenotypic Axis in Gynecological Cancers
26. Diagnostic Biomarkers of Urinary Bladder Cancer and Their Applications: An Update
27. Metabolic Rewiring in Cancer: Understanding the Complexity of Metabolic Networks
28. Energy Balance and Cancer: Understanding the Connection and Implications for Health
29. Metabolic Syndrome As Forecast of Cancer
30. Gene–Nutrient Interaction and Cancer Prevention
31. Dietary Supplements in Cancer Prevention and Therapy
32. Phytochemicals and miRNA-Based Therapeutic Opportunities for Cancer Stem Cell-Mediated Tumor Angiogenesis
33. Machine Learning Techniques in Computer Aided Diagnosis for Effective Detection of Malignant Tissues
34. Deep Learning Techniques for Computer Aided Diagnosis of Various Cancers
35. Long Non-coding RNAs in Cancer
36. MicroRNAs in Cancer: Diagnostics and Therapeutics
37. Histone Chaperones in Cancer
38. Mitochondrial Quality Measures in the Regulation of Tumor Progression and Metastasis
39. Pancreatic Cancer: Pursuit of Mucins from Progression to Prognosis
40. Addressing the Diagnosis and Therapeutics of Malignant Tumor Cells
41. Cellular Interactions Network in Cancer: Integrative Disease Models
42. Crucial Metabolic Networks: Cancer Progression
43. Combating Cancer Using Nanomaterials: Development and Challenges
44. Advances in Cancer Therapeutics: Potential Probiotics on Cancer Therapy
45. Recent Advancements in the Inhibition of Metastasis of Colorectal Cancer Using Anticancer Compounds
46. Cancer Stem Cells
47. Chronology of Anti Cancer Drugs and Their Development
48. Developments in Epigenetic Cancer Therapeutics
49. Challenges and Future Directions of Anticancer Molecules and Their Delivery
50. Pharmacogenomics in Oncology: Current Challenges and Future Strategies
51. Genetic Modulation of Anticancer Drugs Affecting Pharmacokinetic for Safety and Efficacy
52. Exploring the Role of ADME for Anticancer Prodrugs
53. Enhancing the Prodrug ADME Profile: an Emerging Area to Overcome the Issues of Cancer Drug Resistance
54. Role of Pharmacogenomics in Tumor and Therapeutic Outcomes
55. Prognosticating Drug Targets and Responses by Analyzing Metastasis Related Cancer Pathways
56. Potential Pathways for Chemotherapy-induced Cognitive Decline
57. Putting a Magnifying Lens on Pharmacogenetics and Pharmacogenomics Associated Challenges and Opportunities in Area of Cancer Research
58. The Promise of Immunotherapeutics and Vaccines in the Treatment of Cancer
59. An Insight on Colon Cancer Stem Cells and Its Therapeutic Implications
60. Recent Advances in FDA Approved Kinase Inhibitors Targeting Lung Cancer
61. Anti-cancer Potential of Myrica Esculenta Plant: a Comprehensive Review
62. Challenges and Future of Cancer Pharmacogenetics
63. Drug Repurposing for Treatment of Cancer
64. Clinical and Structural Highlights for Nanoparticle Formulations of Anticancer Drugs
65. Nanotechnology in the Formulation and Delivery of Natural Products for Cancer
66. Understanding the Photophysics of Curcumin Inside Nano-Containers: How to Monitor Incorporation and Release Using Fluorescent Techniques
67. Fungal Endophyte-Mediated Green Synthesis of Silver Nanoparticles as Potential Anticancer Agent: Current Perspective and Challenges
68. Fucoidan-based Nanoparticles for the Targeted Delivery of Anticancer Agents
69. Therapeutic Potential of Nanocrystals for Targeting Lymphoid Carcinoma
70. Polysaccharide-Based Nano-Delivery Systems for the Treatment of Colorectal Cancer
71. Potentiation of Thermal Ablation in Cancer Therapy Using Nanomaterials
72. Applications of Nanotechnology in Converging the Biomarker Science for Advancement in Cancer Detection and Treatment
73. Rational Approaches and Design Strategies for Fluorogenic Probes for Cancer Detection, Diagnostics, and Biomarker Research

O autorze

Professor R C Sobti, Sr. Scientist & Professor Emeritus (Former Vice-Chancellor, Panjab University, Chandigarh

Dr. N K Ganguly, FISC, FNAMS, FNASC, FRCP, FICL, FTSL, FTWAS, FACSC, FISC, Former Director, General Indian Council of Medical Research, New Delhi 

​Rakesh Kumar, a molecular cancer biologist, holds the position of Distinguished Emeritus Professor at the Cancer Research Institute, Himalayan Institute of Medical Sciences, India. Professor Kumar is the Founder and Chief Executive Officer of the Breast Cancer in Young Women Foundation, a non-profit international organization based in the United States. The foundation is dedicated to saving the lives of young women affected by breast cancer by promoting awareness and supporting advanced research and advocacy. He is also an adjunct professor at the Rutgers New Jersey School of Medicine and the Virginia Commonwealth School of Medicine in the United States.

Originally hailing from Himalayan hillocks, Professor Kumar's academic journey began with a master's degree in Chemistry from Bareilly College in 1976. Building upon his strong Foundation, he earned his Ph.D. in Biochemistry from the All India Institute of Medical Sciences in New Delhi in 1984. Following a brief stint at All India Institute of Medical Sciences, he embarked on a new chapter in his career by relocating to the Memorial Sloan-Kettering Cancer Center in New York City in January 1986. Throughout his career spanning nearly forty years, he played a significant role as an academician at leading Cancer Centers and Universities in the United States as a tenured faculty since 1996, including more than two decades at the Memorial Sloan-Kettering Cancer Center and the University of Texas MD Anderson Cancer Center. During this time, Professor Kumar held several institutional academic and research leadership positions, served as a department deputy chair and chair, and as an endowed distinguished professor and endowed chairs, in the United States. Alongside his scientific career in the United States, Professor Kumar remained devoted to cancer research and mentoring the country's next generation of scientists in the United States and India. In 2017 he returned to India as a Govt of India National Chair in Cancer Research and Distinguished Professor at the Rajiv Gandhi Center for Biotechnology, where he served until 2022, before joining as a Distinguished Emeritus Professor at the Swami Rama Himalayan University.

Professor Kumar's research contributions have been innovative and pioneering in cancer research. His studies have opened new avenues for further exploration of growth factor receptors, estrogen signaling, and regulatory mechanisms of gene expression. His impact extends beyond academic contributions, with over three hundred research articles, invited reviews in esteemed scientific journals, and authoring nine books or volumes, including the current monograph. Stanford University data from the past three years has consistently ranked Professor Kumar among the under 0.5% of oncology and carcinogenesis scientists globally, highlighting his significant influence in the field. Professor Kumar's excellence isn't limited to research and publications. He has been an active member of various editorial boards for leading cancer research journals for nearly twenty-five years. He continues to serve on the board of several journals at the forefront of cancer research. He has also contributed his scientific expertise to nearly 100 peer-review panels of national and international funding agencies for over three decades, including the National Institutes of Health, Department of Defense, and Veteran Administration of the United States, multiple foreign governmental funding agencies, DBT-Wellcome Trust, India-French and India-German Alliance Funding Programs, Breast Cancer Foundations, and the Monitoring Committee of the National Breast Cancer Genome and the Making Cancer Care Affordable Projects. 

The recognition of Professor Kumar's original research contributions has led to several prestigious awards and honors throughout his career. Notable accolades include the 1995 Outstanding Investigator Award from the Hinkle Society of Penn State University College of Medicine, the 2004 MD Anderson Cancer Center Faculty Achievement Award in Basic Sciences, the 2004 Norman Brinker Award for Research Excellence, the 2006 Ranbaxy (Sun Pharma) Research Award in Pharmaceutical Sciences, the 2013 Lifetime Achievement Award from the American Association of Indian Scientists in Cancer Research. Beyond his research accomplishments, Professor Kumar has made a profound impact as a mentor, guiding and training over 67 graduate students, postdoctoral fellows, and physician-scientists. Many of his mentees now hold esteemed faculty positions at institutions worldwide, including the United States, India, China, Italy, and other countries. Sharing his wealth of knowledge and experience, Professor Kumar has delivered over 280 invited lectures at national and international scientific conferences, universities, medical schools, and hospitals.

In 2023, Professor Kumar's led a significant step by establishing the first Breast Cancer in Young Women Foundation in the United States. The Foundation's mission is to raise awareness globally, support advanced research, and advocate for young women affected by breast cancer. The Foundation's vision is to create a reality in which the death of a young woman from breast cancer becomes a rare event.