Handbook of Neurotoxicity

ISBN-13: 9783031150791 / Angielski / Twarda / 2022 / 2575 str.

Richard M. Kostrzewa

Opis

This handbook is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments - to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model disease entities. Neuroprotection is approached in different manners including those 1) afforded by therapeutic agents - clinical and preclinical; or 2) by non-drug means, such as exercise. The amorphous term 'neurotoxin' is discussed in terms of the possible eventuality of a neuroprotectant producing an outcome of excess neuronal survival and a behavioral spectrum that might produce a dysfunction - akin to a neurotoxin's effect. This new edition significantly expands on the information provided in the first edition, providing the latest research in neurotoxicity and highlighting the relationship between specific neurotoxins and the neurodegenerative disorders they can cause. It also includes new sections on the neurotoxicity of heavy metals, fungi, and snake venom. The Handbook of Neurotoxicity is thus an instructive and valuable guide towards understanding the role of neurotoxins/neurotoxicity in the expansive field of Neuroscience, and is an indispensable tool for laboratory investigators, neuroscientists, and clinical researchers.

Spis treści

Part A

1.       Cell Death Processes: Neurons and Glia

2.       Neuronal Necrosis

3.       Neuronal Apoptosis                                                                       

4.       Autophagy Pathways                                                                    

5.       Necrostatin Neuroprotection                                                                    

6.       Neuronal Necroptosis, Relation to Neurological Disorders                                                                             

7.       Multiple Cell Death Processes in Neurological Disorders                                                                

8.       Micorglia: Neuroprotective and Neurodestructive Properties                                                                       

Part B   

9.       Selective Neurotoxins                                                                                                                   

10.   Survey of Selective Neurotoxinx                                                                                               

11.   RCSN Cell System for Identifying Dopaminergic Neurotoxicity                                                                     

12.   Neurotoxicity: A complex multistage process                                                                                                                                                                                                                                      

Part C   

13.   Dopaminergic and Noradrenergic Neurotoxins                                                                  

14.   Dopamine and L-dopa as Selective Endogenous Neurotoxins                                       

15.   Dopamine D2 Receptor Supersensitivity as a non-Degenerative Neurotoxin          

16.    Trace Amine-Associated Receptor 1 (TAAR1) and Doapmine Receptor Sensitivity

17.   Dopamine Receptor Supersensitivity to Model Schizophrenia      

18.   Pathophysiology of Obsessive-Compulsive Disorder: Insights from Normal Function and Neurotoxic Effects of Drugs, Infection, and Brain Injury                                                             

19.   Dopamine D3 receptors and schizophrenia / drug addiction                                         

20.   Tardive Dyskinesia: Outcome of Antipsychotic Treatment and Brain Damage?      

21.   6-Hydroxydopamine Neurotoxicity in Adult Animals

22.   6-Hydroxydopamine Neurotoxicity in Perinatal Animals                                                 

23.   6-Hydroxydopa in Perinatal and Adult Animals

24.   MPTP Neurotoxicity Mechanisms                                                                                                            

                                                                                                                                               

Part D   

25.   Dopaminergic and Noradrenergic Neurotoxins and Neurodegenerative Disorders              

26.   anti-NGF                                                                                             

27.   Advances in Stem Cell Research for Parkinson's Disease                                                 

28.   Autophagy Pathways and Parkinson's Disease                                                                    

29.   Regulation of DA Homeostasis and Role of VMAT2 in Parkinson's Disease              

30.   Alpha-Synuclein in Parkinson's Disease                                  

31.   Dopaminergic Neurons in Parkinson's Disease                                                    

32.   Dopamine Oxidation and Parkinson's Disease                                                     

33.   Neuromelanin and Parkinson's Disease                                                                                 

34.   Iron-Induced Dopaminergic Cell Death in vivo as a Model of Parkinson's Disease                

35.   Iron Neurotoxicity in Parkinson's Disease                                                                              

36.   6-Hydroxydopamine as Preclinical Model of Parkinson's Disease                                                

37.   MPTP modeling of Parkinson's Disease                                                                                                  

38.   MPTP: Advances from and Evergreen Neurotoxin                                                             

39.   MPTP and Motor Neurons                                                                                                           

40.   MPTP Neurotoxicity: Actions, Mechanisms, and Animal Modeling of Parkinson's Disease

41.   Paraquat and Parkinson's Disease                                                                            

42.   Rotenone Preclinical Modeling of Parkinson's Disease                                                                    

43.   N-Methyl-(R)-Salsolinol and Parkinson's Disease                                                

44.   Fusion Models and "Fusioning" in Parkinsonism: 1-Benzyl-1,2,3,4-tetrahydroisoquinoline

45.   Amphetamines as Neurotoxins 

a.       METH Neurotoxicity                       

b.       Neurotoxicity of MDMA               

46.   Cocaine influence of A2/D2 receptor heteromers                                                                             

47.   Cocaine as a Neurotoxin                                                                                                              

48.   NBOMe Neurotoxicity                                                                                                   

49.   Cathinone Neurotoxicity - several chapters                                                          

50.   Neurotoxic Vulnerability Underlying Schizophrenia Spectrum Disorders  

51.   Molecular Mechanism and Effects of Clostridial Neurotoxins                       

52.   Botulinum Neurotoxicity                                                                                             

53.   ~3 addl subchapters on Botulinum Neurotoxicity                                              

54.   Neurotoxic Effects, Mechanisms, and Outcome of 192-IgG Saporin                           

55.   TRPV1 Activators ("Vanilloids") as Neurotoxins                                                  

56.   Protective Agents in Parkinson's Disease:Caffeine and Adenosine A2A Receptor Antagonists

57.   Physical Exercise as Intervention in Parkinsonism                              

58.   Manganese Neurotoxicity and Parkinson's Disease           

59.   Neuroinflammation and Parkinson's Disease                                                       

60.   Neurotoxicity in Psychostimulant and Opiate Addiction                                  

61.   Homocysteine and Cerebellar Damage                                                                  

62.   Propionic Acid,  Modeling of Autism Spectrum Disorders                                               

63.   1-Me-TIQ, and endogenous Neuroprotectant                                                                                     

64.   5-MeO-DIPT                                                                                      

65.   3-MD-Glutaric acid                                                                                                         

66.   3-NP and Huntington's Disease                                                                                 

67.   25C-NBOMe                                                                                                      

68.   M-30                                                                                                    

69.   Trace amine-associated receptor 1 and neuropsychiatric disorders                                           

70.   PACAP as a Neuroprotectant                                                                                     

71.   Doxycycline as a Neuroprotectant                                                                                                           

72.   PCP Modeling Amnesia                                                                                                 

73.   Drug Abuse Neurotoxicity:                                                                                                          

74.   Alcohol and Nicotine as Developmental Stressors                                             

75.   Neurotrophic Factors and Ethanol Neurotoxicity                                               

76.   Salsolinol and Addiction                                                                                               

77.   Snake Venom Toxins                                                                                                     

78.   Salicylate Ototoxicity                                                                                                     

Part E

79.   Serotoninergic Neurotoxins                                                                                                       

80.   Nature of DSP-4-Induced Neurotoxicity                                                                                 

81.   5,6- and 5,7-Dihydroxytryptamines as Serotoninergic Neurotoxins            

82.   2'NH(2)-MPTP: A Serotonin and Norepinephrine Neurotoxin                                                                                       

Part F                                                                                                                   

83.   Excitotoxins and Excitotoxicity                                                                                                                   

84.   Glutamate as a Neurotoxin                                                                                                         

85.   Aspartate as a Neurotoxin                                                                                                          

86.   Concept of Excitotoxicity via Glutamate Receptors                                                           

87.   Glutamate Neurotoxicity, Transport and Alternative Splicing of Transporters

88.   Excitotoxicity: A Complex Multistage Process Involving Different Mechanisms

89.   Glutamate Excitotoxicity Relation to Energy Failure                                          

90.   Ionotropic Receptors in the Central Nervous System and Neurodegenerative Disorders

91.   Excitotoxicity and Axon Degeneration                                                                    

92.   Glutamate Scavengers                                                                                  

93.   Quinolinate and Related Excitotoxins: Mechanisms of Neurotoxicity and Disease Relevanc

94.   Domoic Acid as a Neurotoxin                                                                                                     

95.   BOAA and Neurotoxicit - several chapters                                                            

96.   Endogenous Kynurenic Acid and Neurotoxicity                                  

97.   Neuroprotection by Kynurenine Metabolites                                                                                      

98.   BMAA (beta-N-Methylamino …..                                                                                               

a.       4 subchapters on BMAA Neurotoxicity                                                                                   

99.   Ionotropic Glutamate Receptors in Neurodegenerative and Other Disorders

100.                       Okadaic acid modeling of Alzheimer's Disease                                                    

101.                       Excitotoxicity in Parkinson's Disease                                                                       

102.                       Excitotoxicity and the Pathogenesis of Gliomas                                                                                  

103.                       Excitotoxicity and Epielpsy; Epilepsy re Neurotoxicity Mechs - one or more addl chapter                                                                                 

104.                       Excitotoxicity in Multiple Sclerosis                                                                           

105.                       Excitotoxicity: Insights into Pathogenesis of AD                                                  

106.                       Excitotoxicity and ALS: Insights into Pathogenesis                             

107.                       Excitotoxicity and Amyotrophic Lateral Sclerosis                                                

108.                       Fungal Neurotoxins and ALS                                                                                       

109.                       Excitotoxicity and Huntington Disease                                                                                                   

110.                       Excitotoxicity and Stroke                                                                                                              

111.                       Excitotoxicity in HIV Associated Neurocognitive Disordders                                                                                                          

112.                       Excitotoxicity and AIDS                                                                                                 

113.                       Excitotoxicity and Neuroprotection in Spinal Cord Injury                                                                                                

114.                       Excitotoxicity in the Pathogenesis of Autism

115.                       Cancer-Mediated Excitotoxicity

116.                       Excitotoxicity and Depression                                                                                                    

117.                       Lead and Excitotoxicity                                                                                                 

118.                       Glutamate and Neurodegeneration in the Retina                              

119.                       Excitotoxicity and Epielpsy                                                                          

120.                       Seizures, Neurotrophin, Neuronal Death                               

121.                       Neurodegenerative Aspets of Multiple System Atrophy                 

122.                       Excitotoxicity in Ischemia and Reperfusion Injury                              

123.                       Molecular, Cellular, and Behavioural Effects Produced by Perinatal Asphyxia:    Neuroprotectants Targeting NMDA Receptor Signaling                                        

124.                       Neuroprotective Strategies in Amyotrophic Lateral Sclerosis Modulation of Neurotransmitory and Neurotrophic Input to Motor Neurons   

125.                       Neuroprotection in Demyelinating Diseases: The Therapeutic Potential of the Neurotrophins                                                                       

126.                       p75NTR: A Molecule with Multiple Functions in Amyloid-beta    

127.                       Metabolism and Neurotoxicity                                  

128.                       Neurotrophins and ALS                                                                                 

129.                       Neurotrophic Factors & NeuroAIDS                                        

130.                       Neuroprotection by Poly (ADP-Ribose) Polymerase 1 (PARP-1) Inhibition                               

                                                                                                               

Part G  

131.                       Alzheimer's Disease and Neurotoxic Aspects                                                       

132.                       Stem Cell Therapies for Age Associated Neurodegeneration        

133.                       Pathogenesis of Alzheimer's Disease                                                                      

134.                       Experimental Approach to Alzheimer Disease                     

135.                       Potential Therapeutic Effects of Statins in Alzheimer's Disease    

136.                       Excitotoxicity and Alzheimer's Disease: Treatment Challenges

137.                       Amyloid-beta, BDNF, and Mechanism of Neurodegeneration in Alzheimer's Diseases

138.                       Drug Treatments: hopes, challenges                                                                       

139.                       Cannabinoids and Alzheimer's                                   

140.                       Heavy Metal Neurotoxicity                                                                                                         

141.                       Trimethyltin Neurotoxicity                                                                                          

142.                       Mn Neurotoxicity                                                                                           

143.                       MeHG                                                                                  

144.                       Cd Neurotoxicity                                                                                             

145.                       Fe Neurotoxicity                                                                                              

146.                       Organoselenium                                                                                             

147.                       Al Neurotoxicity                                                                                              

148.                       Se Neurotoxicity                                                                                              

149.                       Pb Neurotoxicity                                                                                             

Cuprizone modelin of Multiple sclerosis 

O autorze

Richard M. Kostrzewa, Ph.D., Dr.h.c., obtained a Ph.D. (1971) in Pharmacology from the University of Pennsylvania, under the guidance of his Ph.D. advisor and mentor, Dr. David M. Jacobowitz, who became the inaugural Chief of Histopharmacology at the National Institutes of Mental Health. Dr. Kostrzewa, following career stints as Research Pharmacologist at the Veterans Administration Medical Center in New Orleans, Louisiana (1971–1975), adjunct Assistant Professor in the Department of Pharmacology at Tulane Medical School (1974–1976) and Department of Psychology at the University of New Orleans (1974–1977), and Associate Professor at the Louisiana State University Medical Center in New Orleans (1975–1978) joined the faculty of Pharmacology at the newly established Quillen College of Medicine at East Tennessee State University in Johnson City, Tennessee (Assoc. Prof./Professor), and has been a faculty member there for 45 years. Dr. Kostrzewa actively collaborated in research for 20 years with Prof. Ryszard Brus of the Silesian Medical University in Katowice, Poland, where he was Visiting Professor (1997–2003) and from which he received the Doctorate Honoris Causa (2005). In 2001, Dr. Kostrzewa was made an Honorary Member of the Polish Pharmacological Society. His research focus has remained on selective neurotoxins, with applications in the areas of nerve regeneration and sprouting, neurodegenerative disorders, dopamine receptor supersensitivity, and modeling of Parkinson’s disease, attention-deficit hyperactivity disorder, tardive dyskinesia, schizophrenia, and other neurologic disorders. He has authored and edited more than 10 books and more than 200 scientific papers, including the article “Pharmacological Actions of 6-Hydroxydopamine,” which in 1994 was designated in Current Contents as a “Citation Classic,” being one of the 400 most-cited papers at that time. Dr. Kostrzewa was co-founder with Prof. Dr. Juan Segura-Aguilar (University of Chile) of the Neurotoxicity Society, serving as its inaugural President, as the Society’s Treasurer for 10 years, and as its Secretary. Founder of the journal Neurotoxicity Research, he was its inaugural Editor-in-Chief, and he has served in that capacity for 24 years.