Handbook of Incretin-Based Therapies in Type 2 Diabetes

ISBN-13: 9783319089812 / Angielski / Miękka / 2016 / 92 str.

Stephen Gough

Opis

This concise handbook provides an overview of incretin-based therapies and guidance for incorporating them into the treatment of type 2 diabetes. Chapters include landmark clinical trials and international treatment guidelines in order to update readers with all major advances in the field. An ideal resource for medical professionals that treat patients with type 2 diabetes in hospital and clinical settings.

Spis treści

1. Introduction and disease overview

References

2. Incretin hormones as a target for therapy

Incretin hormone physiology 

The incretin-producing cell

GIP and GLP-1 action

Measurement of the incretin hormones

Incretin action in healthy individuals

Incretin action in patients with type 2 diabetes

Therapeutics application

References

3. Glucagon-like peptide receptor agonists 

Introduction 

GLP-1 receptor agonists 

Extrapancreatic effects GLP-1 receptor agonists 

Pancreatic safety 

Perspectives 

References 

4. Dipeptidyl peptidase-4 inhibitors 

Introduction 

Pharmacokinetics and pharmacodynamics 

Efficacy 

Combination therapy 

Use in specific patient populations 

Conclusions 

References 

5. Global position and recommendations for use 

Introduction 

American Association of Clinical Endocrinologists/American College of Endocrinology

American Diabetes Association /European Association for the Study of Diabetes

International Diabetes Federation 

National Institute of Health and Care Excellence 

Using incretin-based therapies in clinical practice 

Availability and licences 

References 

6. Future and emerging therapies 

Introduction 

Once-weekly agents under investigation 

Subcutaneous implants 

Investigational DPP-4 inhibitors and fixed-dose combination with SGLT2 inhibitors 

Other indications for incretin therapies

DPP-4 inhibitors

References                                                                                                                                                                                                            

O autorze

Stephen Gough is Professor of Diabetes at the University of Oxford and Consultant Physician at the Oxford University Hospitals NHS Trust. Professor Gough graduated in medicine from Leeds University Medical School, where he was later awarded a higher degree Doctorate in Medicine, which focused on cardiac dysfunction and abnormalities in coagulation and fibrinolysis present at the time of diagnosis of type 2 diabetes. He is currently based at the Oxford Centre for Diabetes, Endocrinology and Metabolism, where he is a practicing clinician in diabetes. His research interests and ongoing research studies include translational aspects of diabetes, with a focus on the physiology of islet cell and whole organ pancreas transplantation, incretin biology, and incretin therapies in diabetes. Professor Gough has previously had a strong interest in the genetic susceptibility to autoimmunity and this work has been extended into his work on pancreas transplantation. He has published his research extensively in peer-reviewed journals and has contributed to many national and international conferences and books on diabetes. In recent years, Professor Gough has helped develop translation research in diabetes in Oxford through a number of local and national initiatives, including the Oxford Biomedical Research Centre, and he is Clinical Lead in Diabetes for the Oxford Academic Health Science Network and the Oxford Local Clinical Research Network.

Addendum

Since editing this book, Professor Gough has taken up the position of Senior Principal Clinical Scientist with Novo Nordisk. He continues as Visiting Professor of Diabetes at the University of Oxford and Honorary Consultant with the Oxford University Hospitals NHS Trust.