Handbook of Epigenetics: The New Molecular and Medical Genetics

ISBN-13: 9780128053881 / Angielski / Twarda / 2017 / 682 str.

Trygve Tollefsbol

Opis

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders.

• Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field
• Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine
• Written at a verbal and technical level that can be understood by scientists and college students
• Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials

Spis treści

1. An Overview of Epigenetics

SECTION I:  Molecular Mechanisms of Epigenetics 2. Mechanisms of DNA Methylation 3. Molecular Mechanisms of Histone Modification 4. The Epigenetics of Non-coding RNA

SECTION II:  Additional Epigenetic Processes 5. Prions in Epigenetic Inheritance 6. Chromosomal Position Effects 7. Polycomb-group Proteins and Epigenetics

SECTION III:  Epigenetic Technology 8. Analyses of Gene-specific DNA Methylation 9. Methods for Assessing Genome-wide DNA Methylation 10. Determination of Histone Modifications of Specific Genes 11. Analyses of Genome-wide Histone Modifications 12. Techniques for Genome-wide Expression of Non-coding RNA 13. Computational Epigenetics

SECTION IV:  Model Organisms of Epigenetics 14. Epigenetics of Lower Organisms 15. Drosophila Epigenetics 16. Models of Mouse Epigenetic Inheritance 17. Plant Epigenetics

SECTION V:  Metabolism and Epigenetics 18. Metabolic Effects on DNA Methylation 19. Metabolism and Chromatin Dynamics

SECTION VI:  Functions of Epigenetics 20. Epigenetics, Stem Cells and Cellular Differentiation 21. Regeneration Epigenetics 22. Epigenetics of X-chromosome Inactivation 23. Genomic Imprinting 24. Epigenetics of Memory Processes 25. Transgenerational Epigenetics 26. Aging Epigenetics

SECTION VII:  Evolutionary Epigenetics 27. Evolution of Epigenetic Mechanisms 28. Adaptive Evolution and Epigenetics

SECTION VIII:  Epigenetic Epidemiology 29. The Effects of Diet on Epigenetic Processes 30. Environmental Agents and Epigenetic Effects 31. Impact of Infective Agents on the Epigenome 32. Population Pharmacoepigenomics

SECTION IX:  Epigenetics and Human Disease 33. Cancer Epigenetics 34. The Role of Epigenetics in Immune Disorders 35. Epigenetics of Brain Disorders 36. The Epigenetics of Metabolic Diseases 37. Imprinting Defects in Humans

SECTION X:  Epigenetic Therapy 38. DNA Demethylating Agents in Clinical Medicine 39. Clinical Applications of Histone Deacetylase Inhibitors 40. Combination Epigenetic Therapy

SECTION XI:  The Future of Epigenetics 41. New Directions for Epigenetic Research

O autorze

Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor's degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.