Handbook of Eicosanoids (1987): Volume I, Part B

ISBN-13: 9781138105737 / Angielski / Twarda / 2017 / 288 str.

A. L. Willis

Opis

Building upon the extensive compilation of biochemical data featured in Volume I of the Handbook of Eicosanoids, the new Volume II describes the past, present, and potential future impact of eicosanoid research on new drug development. The reader is taken from a historical perspective through state-of-the-art basic concepts to extensive tabulation of molecular structures of compounds known to act via the eicosanoid system.

Spis treści

INTRODUCTION TO THE AREA. Therapeutic Promise of the Eicosanoid Area: An Overview. INHIBITORS OF EICOSANOID PRODUCTION. Antiphospholipase Proteins: Introduction and Overview. Effects of Corticosteroids on Release of Eicosanoid Precursors. Drugs that Inhibit the Activities or Activation of Phospholipases and Other Acylhydrolases. Cyclooxygenase Inhibitors. Lipoxygenase Inhibitors. Selective Inhibitors of Thromboxane Synthetase. MODULATORS OF EICOSANOID ACTIONS. Classification of Prostanoid Receptors. Eicosanoid Receptor Antagonists. Leukotriene Antagonists. Regulation of Cyclic Nucleotide Metabolism in Human Platelets by Prostanoids. Opposite Effects of Prostaglandins on Human Platelets Mediated by Distinct Protein Kinases.