Handbook of Dystonia

ISBN-13: 9781841848518 / Angielski / Twarda / 2012 / 440 str.

Mark A. Stacy

Opis

As many as 250,000 people in the US have dystonia, making it the third most common movement disorder following essential tremor and Parkinson's disease.This authoritative reader-friendly resource provides a wide-ranging overview of the latest research and developments regarding the pathogenesis, evaluation, and management of the disease. Offering detailed coverage of every available treatment option for dystonia, including four categorized sections on medical management, botulinum toxin injections, phenol or neurolytic therapy, and surgical intervention. This source summarizes what is known about the disorder and dramatically improves the recognition and understanding of this debilitating disease.The most important update to the second edition is the addition of four new chapters dedicated to the discussion of individual botulinum toxins recently approved to treat dystonia: Botox, Myobloc, Disport, and Xeomin. Other new chapters include a discussion of rapid-onset dytonia-parkinson's, dystonic synptoms associated with parkinson's disorders, the use of Transcranial Magnetic Stimulation (TMS) as a treatment option for dystonia, as well as a chapter dedicated to spasticity, its pathogenesis, evaluation, and treatment with toxins, other injectables or surgical therapies.

Spis treści

SECTION I: EPIDEMIOLOGY AND PATHOGENESIS: Introduction to Dystonia. Epidemiology Dystonia. Genetic Evaluation in Hereditary Dystonia . Functional Anatomy of the Basal Ganglia . Physiology of Primary Dystonia. Pathology of the Dystonias. Neuroimaging in Dystonia. SECTION II: SIGNS AND SYMPTOMS: Primary Generalized Dystonia. Cranial Dystonia. Cervical Dystonia. Limb Dystonia. Spasmodic Dysphonia. Embouchure and Other Task-Specific Musician’s Dystonias. Sports-Related Task-Specific Dystonia: The Yips. Dopa-Responsive Dystonia. Rapid Onset Dystonia-Parkinson. Secondary Dystonia. Dystonic Symptoms Associated with Parkinsonian Disorder. Drug-Induced Dystonia. Psychogenic Dystonia. Nonmotor Symptoms in Dystonia. Spasticity. SECTION III: TREATMENT OPTIONS: Medical Therapy for Dystonia. Anatomic Principles for Botulinum Toxin Injection. Botulinum Toxin: From Molecule to Clinic. Botulinum Toxins in the Treatment of Dystonia. Botox onabotulinumtoxinA. Myobloc rimabotulinumtoxinB. Dysport abobotulinumtoxinA. Xeomin incobotulinumtoxinA. Peripheral neurolysis in the treatment if dystonia. Selective Denervation in Cervical Dystonia. Repetitive transcranial Magnetic Stimulation in the Treatment for Dystonia. Brain Surgery for Dystonia.