Handbook of Dynein (Second Edition)

ISBN-13: 9789814800013 / Angielski / Twarda / 2019 / 420 str.

Keiko Hirose

Opis

Since the first edition of this book was published in 2012, there has been a significant breakthrough: the crystal structures of the motor domains of cytoplasmic dynein have been solved and the previously unknown details of this huge and complex molecule have been unveiled.

Spis treści

Dyneins: Ancient Protein Complexes Gradually Reveal Their Secrets.  Structural and Functional Analysis of the Dynein Motor Domain.  Electron Microscopy Studies of Dynein: From Subdomains to Microtubule-Bound Assemblies.  Subunit Architecture of the Cytoplasmic Dynein Tail.  Measuring the Motile Properties of Single Dynein Molecules.  Mechanics of Dynein: Motility.  Interactions of Multiple Dynein Motors Studied Using DNA Scaffolding.  Cytoplasmic Dynein Force Regulation in Vitro and in Vivo.  Dynein in Endosome and Phagosome Maturation.  Dynein in Intraflagellar Transport.  Diversity of Chlamydomonas Axonemal Dyneins.  Motility of Axonemal Dyneins  Axonemal Dyneins in Cilia and Flagella.  Regulatory Mechanism of Axonemal Dynein.

O autorze

Keiko Hirose is a researcher with more than 30 years’ experience in structural and functional studies of motor proteins. She has a PhD from the University of Tokyo and was a postdoctoral fellow at the University of Pennsylvania and at the MRC Laboratory of Molecular Biology, Cambridge, UK. She is especially interested in how molecular motor proteins, such as dynein, move. Dr. Hirose has been working at the National Institute of Advanced Industrial Science and Technology, Japan, since 1997.