Handbook of Drug Monitoring Methods: Therapeutics and Drugs of Abuse

ISBN-13: 9781617377730 / Angielski / Miękka / 2010 / 446 str.

Amitava Dasgupta

Opis

Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.

Recenzje

From the reviews:

"This is a comprehensive handbook on all aspects of drug monitoring. ... This has broad appeal. Of course it would appeal to anyone actively measuring drug levels (i.e., clinical laboratory scientists, toxicologists, clinical chemists). It would also appeal to anyone interested in how such testing is performed and the pitfalls in interpreting results (students or practitioners in any medical discipline or allied health field, poison control centers, concerned parents, etc.). ... This is a very nice addition to the field of drug testing and monitoring." (Valerie L., Doody's Review Service, February, 2008)

"This book addresses the issues of therapeutic drug monitoring but also includes information about drugs of abuse, natural products and toxic elements. ... The volume is an ideal reference for clinical laboratories ... . A sturdy construction, good quality paper, a pleasant layout, the inclusion of graphs and diagrams, as well as chemical structures, copious relevant references and a detailed index make this an extremely useful book. If this is your field then this book should be with you." (Steve Mitchell, International Society for the Study of Xenobiotics Newsletter, Spring, 2008)

"A comprehensive textbook covering the theory and practice of drug analysis as well as the reasons behind the methods, their advantages, pitfalls and even what one does with the measurements after they have been acquired. ... To find a text that not only covers all aspects but flows so well across the disciplines is a real rarity. ... It really is unusual to see theory and practice sitting together so comfortably. Overall a refreshing change to books with similar titles ... ." (Graham Lappin, British Toxicology Society Newsletter, Summer, 2008)

"This book is meant to be 'a handbook at the bench of a clinical laboratory' to serve as a quick reference to find the source of a false positive or a false negative result. ... also be useful for various other laboratory personnel including toxicologists and pathologists. ... The book maintains its 'handbook' style throughout with each chapter written in a precise and concise manner using very readable language. ... would be very useful to a variety of medico-legal scientific disciplines including forensic toxicologists." (William Westenbrink, Canadian Society of Forensic Science Journal, August, 2008)

Aus den Rezensionen: "... Die angesprochenen Themen werden ausführlich und in alter gebotenen wissenschaftlichen Tiefe abgehandelt ... Das Buch eignet sich somit hervorragend als Referenz für alle, die auf diesem Gebiet tätig sind. ... Neben einer guten Einleitung, die einen schnellen Überblick über das Gebiet verschafft, finden sich Kapitel zur Verfälschung von Probenmaterial ... Zusammenfassend handelt es sich bei dem vorliegenden Buch um ein interessantes Nachschlagewerk für alle, die sich mit Therapeutischem Drug-Monitoring und/oder dem Nachweis von Drogen beschäftigen ..." (Priv.-Doz. Dr. med. Werner Steimer, in: Laboratoriums-Medizin: journal of laboratory medicine, 2009, Vol. 33, Issue 1, S. 39)

Spis treści

Content 1. Chapter 1: Introduction to Therapeutic Drug Monitoring. Amitava Dasgupta, Ph.D. Department of Pathology and Laboratory Medicine, University of Texas-Houston, Medical School, Houston, TX 2. Chapter 2. Monitoring Free Drug Concentration. Amitava Dasgupta, Ph.D. Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, Houston, TX. 3. Chapter 3. Analytical Techniques for Measuring Concentrations of Therapeutic Drugs in Biological Fluids. Amitava Dasgupta and Pradip Datta. Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, Houston, Texas and Bayer HealthCare, Diagnostics Division, Tarrytown, NY 4. Chapter 4. The Pre-Analytical Phase of Drug Testing: From Specimen Collection to Analysis. Catherine A. Hammett-Stabler, Ph.D. Department of Pathology and Laboratory Medicine University of North Carolina at Chapel Hill 5. Chapter 5. Effect of Hemolysis, High Bilirubin, Lipemia, Paraproteins and System Factors on Therapeutic Drug Monitoring. Pradip Datta, PhD. Bayer HealthCare, Diagnostics Division, Tarrytown, NY 6. Chapter 6: Digoxin: So Many Interferences and How to Eliminate Them. Amitava Dasgupta, Ph.D. Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, Houston, TX 7. Chapter 7. Interferences with Measurement of Anticonvulsants. William Clarke, Ph.D. Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 8. Chapter 8. Pitfalls in Measuring Antidepressant Drugs. Uttam Garg, Ph.D. Department of Pathology and Laboratory Medicine University of Missouri, Kansas City and Children's Mercy Hospitals and Clinics, Kansas City, MO. 9. Chapter 9. Immunosuppressive Drugs: Pharmacokinetics, Preanalytic Variables, and Analytical Considerations. Anthony W. Butch, Ph.D. Department of Pathology and Laboratory Medicine, Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095-1732 10. Chapter 10. Therapeutic Drug Monitoring in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome. Steven J Soldin PhD. Department of Pharmacology, Georgetown University and Department of Laboratory Medicine, Children’s National Medical Center 11. Chapter 11. Pharmacogenomics and Personalized Medicine: Issues and Methodology. Steven H. Y. Wong. Department of Pathology, Medical College of Wisconsin And Toxicology Department, Milwaukee County Medical Examiner’s Office, Milwaukee, WI, 12. Chapter 12. Interference of Heterophilic and Other Antibodies in Measurement of Therapeutic Drugs by Immunoassays. Pradip Datta, PhD. Bayer HealthCare, Diagnostics Division, Tarrytown, NY 13. Chapter 13. Drug-Herb and Drug-Food Interactions: Impact on Therapeutic Drug Monitoring. Amitava Dasgupta, Ph.D Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, Houston, TX 14. Chapter 14. Toxic Element Testing with Clinical Specimens. Gwendolyn A. McMillin, Ph.D.1,2 and Joshua A. Bornhorst, Ph.D. 3 1 ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, 2 Department of Pathology, University of Utah, Salt Lake City, Utah 84132, 3 Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 15. Chapter 15. Alcohol Testing. Steve C. Kazmierczak, Ph.D and Hassan ME Azzazy, Ph.D. Department of Pathology, Oregon Health & Science University, Portland, Oregon and Department of Chemistry, The American University of Cairo, Egypt 16. Chapter 16. Introduction to Drugs of Abuse Testing. Tai C. Kwong, Ph.D. Department of Pathology, University of Rochester Medical Center, Rochester, NY 17. Chapter 17. Urinary

O autorze

In this handbook, the authors discuss the different analytical techniques used in today s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing. The volume s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor.
This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem.

Blurb

In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem. The volume’s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor. Comprehensive and timely, Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse is the ideal text for clinicians and researchers monitoring alcohol and drug testing and other important tasks of toxicological laboratory services.