Handbook of Comparative Genomics: Principles and Methodology

ISBN-13: 9780471391289 / Angielski / Twarda / 2003 / 442 str.

Cecilia Saccone; Graziano Pesole; C. Saccone

Opis

This comprehensive reference covers the comparative methodology involved in studying molecular evolution. Providing a practical introduction to the role of bioinformatics in comparative genomics, this publication further discusses the basic technology used in genome sequencing projects and provides an overview of genome storage databases currently in use. This timely and cutting-edge text also:

• Reviews the basic principles of genomics and gene expression analysis
• Discusses analytic methods in proteomics and transcriptomics
• Includes a comprehensive list of Web resource

Recenzje

" an excellent addition to the field of comparative genomics." ( ASM News, December 2004)

...will provide interesting reading and perspective to almost everyone involved in biological sciences. (Quarterly Review of Biology, March 2004)

"...certainly deserves a place in institutional libraries...depth of material covered is right for the busy scientist...precise and detailed..." (Briefings in Functional Genomics & Proteomics, Vol 2(4), February 2004)

"...this book gives an illuminating look at the study of genomes through their sequence..." (Human Genomics, January 2004)

"...covers basic and applied problems in the emerging field of comparative functional genomics..." (Genetic Engineering News, Vol 23(14), 2003)

Spis treści

SECTION I: GENOME FEATURES.

Preface.

The Prokaryotic Genome.

Eukaryotes.

Organelles.

SECTION II: METHODOLOGIES.

Molecular Biology Techniques for Genomics.

Biological Databases.

Computatonal Methods for the Analysis of Genome Sequence Data.

SECTION III: COMPARATIVE GENOMICS.

Molecular Evolution.

Molecular Phylogeny.

Appendix I.

O autorze

Cecilia Saccone is Professor of Molecular Biology at the University of Bari as well as the chair of the National Research Council (CNR) in Bari, Italy.

Graziano Pesole is a professor in the Department of Physiology and General Biochemistry at the University of Milan, Italy.

Blurb

Handbook of Comparative Genomics: Principles and Methodology is a practical text for students and researchers covering basic and applied problems in the emerging field of comparative functional genomics. It offers a comparative perspective on the state of the art and key principles of genome sequencing, expression, evolution, and phylogenetics in organelles, prokaryotes, model organisms, and humans. Moreover, the Handbook provides a unique and thorough treatment of biological databases, analysis of the transcriptome and proteome, and the bioinformatic approaches for comparative genome analysis.

The text begins with an introduction to important features of completely sequenced genomes from mitochondria, C. elegans and Arabidopsis to Drosophila and humans. The next section covers cutting–edge analytic approaches involving ESTs, SAGE, DNA microarrays, protein biochips, and 2D gel electrophoresis. The following section deals comprehensively with computational approaches to comparative genome and proteome sequence analysis, including sequence assembly, pattern searching, gene and protein function prediction, and structure prediction. The text concludes with a section discussing genome evolution and molecular phylogenetics. This timely and cutting–edge text also:

• Presents both the concepts and methodology of comparative genomics
• Reviews the basic principles of genomics and gene expression analysis
• Covers the bioinformatics approaches to comparative analysis
• Discusses analytic methods in proteomics and transcriptomics
• Includes a comprehensive list of Web resources

The authors draw upon their wealth of teaching and research experience to offer a coherent presentation appropriate for students, trainees, researchers, and scientists across the life sciences.