HIV I: Molecular Biology and Pathogenesis: Clinical Applications: Volume 56

ISBN-13: 9780123736017 / Angielski / Twarda / 2007 / 593 str.

Ferid Murad

Opis

Although it is one of the most-widely studied viruses, many mysteries still remain about HIV. Covering the latest advances and challenges associated with clinical application of new antiviral drugs and vaccines, this revised edition is a companion to Murad: HIV-1: Molecular Biology and Pathogenesis, Second Edition. Leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus.

• The latest developments in HIV-vaccine research
• New concepts in the discovery and design of novel anti-HIV drugs

Spis treści

HIV Therapeutics: Past, Present, and Future
HIV Drug Resistance and Viral Fitness
Inhibitors of HIV-1 Reverse Transcriptase
HIV-I Protease: Maturation, Enzyme Specificity, and Drug Resistance
HIV-I Integrase Inhibitors: Past, Present, and Future
Selection of HIV Replication Inhibitors: Chemistry and Biology
Maturation or assembly inhibitor compounds against HIV-1
HIV-I Gene Therapy: Promise for the Future
Assessment of HIV Vaccine Development: Past, Present, and Future
CTL immunity approaches for HIV-1 vaccines
humoral immunity approaches for HIV-1 vaccines.
HIV-I-Associated Central Nervous System Dysfunction
Molecular Mechanisms of Human Immunodeficiency Virus Type I Mother-Infact Transmission
Molecular Epidemiology of HIV-I: An Example of Asia
Simian Immunodeficiency Virus Infection of Monkeys as a Model System for the Study of AIDS Pathogenesis, Treatment and Prevention
Animal Models for AIDS Pathogenesis
SCID-hu mouse models for studying HIV-AIDS and for drug testing.

O autorze

Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children.