Gut-Associated Lymphoid Tissues

ISBN-13: 9783540306566 / Angielski / Twarda / 2006 / 210 str.

Tasuku Honjo;Fritz Melchers

Opis

The intestine is colonized by an impressive community of commensals, that has profound effects on the immune funtions. The relationship between gut microbiota and the immune system is one of reciprocity: commensals have important contribution in nutrient processing and education of the immune system and conversely, the immune system, particularly gut-associated lymphoid tissues plays a key role in shaping the repertoire of gut microbiota.

Spis treści

Preface.- Role of the Innate Immune System and Host-Commensal Mutualism.- Molecular Networks Orchestrating GALT development.- Lymphoid Tissue Inducer Cells in Intestinal Immunity.- Lymphocyte Homing to Gut Mucosa.- IGA Adaptation to the Presence of Commensal Bacteria in the Intestine.- Intestinal IgA Synthesis. A Primitive From of Adaptive Immunity that Regulates Microbial Communitities in the Gut.- B Cell Recruitment and Selection in Mouse GALT Germinal Centers in Response to Commensal Flora, in the Absence of BCR-Mediated Antigen Recognition.- Structural Insights Into Antibody-Mediated Mucosal Immunity.- Subject Index.