Greenfield's Neuropathology 10e Vol 1

ISBN-13: 9781032481371 / Angielski

Colin Smith; Thomas Jacques; Gabor Kovacs

Opis

Greenfield's 10e is the world’s leading neuropathology reference. The two volume work provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The key reference for scientists, clinicians, researchers, and students.

Spis treści

Volume One. Section 1: General Pathology of the Nervous System. Diseases of brain synapses and neuronal architecture. Astrocyte functions in health and disease. Oligodendrocytes. Microglia. Ependymal cells and choroid plexus. Cellular inclusions and artefacts. Basic Pathophysiology. Section 2: Cerebrovascular Disorders.Vascular disease, hypoxia and consequences. Section 3: Developmental Neuropathology and Metabolic Disorders. Normal development of the nervous system. Acquired disorders of childhood. Malformations. Metabolic and degenerative disorders of childhood. Lysosomal disorders. Peroxisomal disorders,Mitochondrial disorders. Section 4: Epilepsy.Epilepsy pathology. Section 5: Neuroinflammatory Disorders Multiple sclerosis and other demyelinating conditions. Other immune-related disorders affecting the nervous system.Section 6: Neurodegenerative disorders.Neurodegenerative diseases: classification. Pathogenesis and concepts. Movement disorders. Degenerative ataxic disorders. Motor neuron disorders. Cognitive decline. Neurodegenerative proteinopathies: PrP proteinopathies. Neurodegenerative proteinopathies: Alzheimer’s disease (A-beta and Tau proteinopathy). Neurodegenerative proteinopathies: Synuclein proteinopathies. Neurodegenerative proteinopathies:Tau proteinopathies. Neurodegenerative proteinopathies: TDP-43 proteinopathies. Neurodegenerative proteinopathies: FUS/FET proteinopathies. Neurodegenerative proteinopathies: Trinucleotide repeat disorders. Miscellaneous proteinopathies and neurodegenerative conditions. Ageing-related pathologies of the brain. Mixed pathologies of the ageing and neurodegenerating brain.Diagnostic approach to the neuropathology of neurodegenerative diseases

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O autorze

Professor Colin Smith, Chair of Neuropathology, Centre for Clinical Brain Sciences,Centre for Comparative Pathology,The University of Edinburgh, Scotland, UK. Graduated MBChB from Glasgow 1992, and FRCPath 2000. Appointed Senior Lecturer in Pathology in 2001 and has both a diagnostic and research component to his role. Main research interests lie around neurotrauma and neurovascular disease, and particularly assessment of human tissue in these disorders. Professor Tom Jacques, Professor of Paediatric Neuropathology, ICH Development Bio & Cancer Programme,UCL GOS Institute of Child Health, London, UK. Gabor G Kovacs, MD, PhD, FRCPC is Professor in the Department of Laboratory Medicine and Pathobiology at the University of Toronto, a Consultant Neuropathologist at the Laboratory Medicine Program (LMP) at the University Health Network (UHN) and a Principal Investigator at the Tanz Centre for Research in Neurodegenerative Disease. He is also a Senior Scientist at the Krembil Brain Institute, a Faculty member of the Edmond J. Safra Program in Parkinson's Disease and the Co-Director of the Rossy Program for Progressive Supranuclear Palsy Research (UHN).