Gold and Its Complexes in Anticancer Chemotherapy

ISBN-13: 9789813363168 / Angielski / Miękka / 2022

Mohmmad Younus Wani; Manzoor Ahmad Malik

Opis

This book presents an overview of cancer and the genesis, and development of different treatment strategies and modalities against cancer. The emergence of gold and its complexes as promising anticancer chemotherapeutic agents have the potential to substitute or replace the platinum based chemotherapeutic agents. Gold complexes have demonstrated considerable anti-proliferative properties, chiefly attributed to their anti-mitochondrial effects, they make gold complexes excellent candidates as anti-cancer agents compared to their platinum-based counterparts. This book provides a critical review of recent advances made in the development of gold complexes as anti-cancer agents. In this context, it examines a number of different ligand architectures, provides comprehensive information on gold complexes’ mechanism of action and toxicity issues and, in closing, outlines future research directions.

Spis treści

1. Introduction

2. Gold and its Complexes in Medicine

3. Gold and its Complexes in Anticancer Chemotherapy

4. Classes of Gold Complexes as Anticancer Agents

    4.1. Complexes with Nitrogen Donar Ligands

    4.2. Complexes with Sulphur Donar Ligands

    4.3. Complexes with Phosphorus Donar Ligands

    4.4. Complexes with Sulphur-Phosphorus Donar Ligands

    4.5. Organometallic Gold Complexes

    4.6. Macrocyclic Gold Complexes

    4.7. Miscellaneous Gold Complexes

5. Mechanisms of Action of Anticancer Gold Complexes

6. Gold based therapy against platinum based therapy.

7. Toxicity Issues with Gold Complexes

8. Future Research Outlooks

O autorze

Dr. Wani graduated from Jamia Millia Islamia, New Delhi, India in 2013. Received a senior research fellowship from CSIR-India and FCT postdoctoral fellowship from Portugal. Worked as a postdoctoral fellow with Prof. A. Sobral group from 2013-2016 on the development of fungal cell wall targeted antifungal therapies. In fall 2016, Dr. Wani moved to the University of Texas, USA and worked with Dr. K. Tsuchikama’s group at Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, UTHealth on the development of non-traditional antimicrobial agents and peptide based cleavable linkers for ADC’s. In fall 2017, Dr. Wani was appointed as assistant professor in Chemistry Department, Faculty of Sciences, University of Jeddah, KSA. Dr. Wani continues to work on the development of new small molecules, metal complexes and novel strategies to combat microbial infections and cancer at the interface of chemistry and biology. He has many international publications, book chapters, and two books, besides many international and national honors and awards to his credit. Dr. Wani is working hard to advance the medicinal chemistry and drug discovery field with new questions and pertinent issues of 21st century.

Manzoor Ahmad Malik was born and raised in district Pulwama of Jammu and Kashmir, India. He did his BSc. from University of Kashmir and received his Master’s in Chemistry from the Department of Chemistry, Jamia Millia Islamia, New Delhi, India. Dr. Malik received M. Phil in Chemistry from Jiwaji University, and Ph.D. from Jamia Millia Islamia, New Delhi, India. He received a Senior Research Fellowship from CSIR, India in 2019. He has several international publications including research articles and book chapters to his credit. His research interests include, design and synthesis of small molecule inhibitors and metal complexes for microbial infections and cancer. Dr. Malik is currently working on the development of non-platinum metal complexes that could be used for anticancer chemotherapy with better efficacy and less toxicity compared to the platinum drugs used in cancer therapy.