Glycobiology of the Nervous System

ISBN-13: 9781493946372 / Angielski / Miękka / 2016 / 584 str.

Robert Yu; Cara-Lynne Schengrund

Opis

A thorough introduction is provided to the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system.

Spis treści

1 Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates
Veer P. Bhavanandan, D. Channe Gowda

2 Introduction to Cells Comprising the Nervous System
Douglas G. Peters, James R. Connor

3 Synthesis, Processing, and Function of N-glycans in N-glycoproteins
Erhard Bieberich

4 Synthesis of O-linked Glycoconjugates in the Nervous System
Jin-Ichi Inokuchi, Shinji Go, Yoshio Hirabayashi

5 Chemistry and Function of Glycosaminoglycans in the Nervous System
Nancy B. Schwartz, Miriam S. Domowicz

6 Use of Glycan-targeted Antibodies/Lectins to Study the Expression/Function of Glycosyltransferases in the Nervous System
Yasuhiko Kizuka, Kenji Kanekiyo, Shinobu Kitazume, Naoyuki Taniguchi

7 From Mass Spectrometry-based Glycosylation Analysis to Glycomics and Glycoproteomic
Kay-Hooi Khoo

8 Structural Analysis of Oligosaccharides and Glycoconjugates using NMR
Yoshiki Yamaguchi, Takumi Yamaguchi, Koichi Kato

9 Glycolipid and Glycoprotein Expression During Neural Development
Robert K. Yu, Yutaka Itokazu

10 Gangliosides and Cell Surface Ganglioside Glycohydrolases in the Nervous System
Massimo Aureli, Maura Samarani, Valentina Murdica, Laura Mauri, Nicoletta Loberto, Rosaria Bassi, Alessandro Prinetti, Sandro Sonnino

11 Role of Myelin-Associated Glycoprotein (Siglec-4a) in the Nervous System
Pablo H.H. Lopez

12 Role of Galactosylceramide and Sulfatide in Oligodendrocytes and CNS Myelin: Formation of a Glycosynapse
Joan M. Boggs

13 Glycosignaling – A General Review
Glyn Dawson

14 Glycosphingolipids in the Regulation of the Nervous System
Koichi Furukawa, Yusuke Ohmi, Yuki Ohkawa, Orie Tajima, Keiko Furukawa

15 Glycobiology of Ion Transport in the Nervous System
Martha C. Nowycky, Gusheng Wu, Robert W. Ledeen

16 O-GlcNAcylation of Neuronal Proteins: Roles in Neuronal Functions and in Neurodegeneration
Olof Lagerlöf, Gerald W. Hart

17 N-glycosylation in Regulation of the Nervous System
Hilary Scott, Vladislav M. Panin

18 Roles of Carbohydrates in the Interaction of Pathogens with Neural Cells
Cara-Lynne Schengrund

19 Glycoconjugate Changes in Aging and Age-related Diseases
Susumu Ando

20 Gangliosides and Glycolipids in Neurodegenerative Disorders
J. S. Schneider

21 Glycosidases: Inborn Errors of Glycosphingolipid Catabolism
Hisashi Ashida, Yu-Teh Li

22 Ganglioside Storage Diseases: On the Road to Management
Thomas N. Seyfried, Hannah E. Rockwell, Karie A. Heinecke, Douglas R. Martin, Miguel Sena-Esteves

23 Dynamic Aspects of Neural Tumor Gangliosides
Stephan Ladisch, Yihui Liu

24 Galectins and Neuroinflammation
Hung-Lin Chen, Fang Liao, Teng-Nan Lin, Fu-Tong Liu

25 Glycoconjugates and Neuroimmunological Diseases
Hugh J. Willison

O autorze

Cara-Lynne Schengrund, PhD, is Professor Emeritus, Department of Biochemistry and Molecular Biology, Penn State University, Hershey, Pennsylvania

Robert K. Yu, PhD, Med ScD, is Professor, Department of Neuroscience and Regenerative Medicine, and GRA Eminent Scholar in Molecular and Cellular Neurobiology, Medical College of Georgia at Augusta University, Augusta, Georgia

Blurb

A thorough introduction is provided to the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic information as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. The breadth and depth of topics covered make it an essential reference for those new to the field as well more seasoned investigators.