Glycerophospholipids in the Brain: Phospholipases A2 in Neurological Disorders

ISBN-13: 9781493902101 / Angielski / Miękka / 2014 / 394 str.

Akhlaq a Farooqui;Lloyd a Horrocks

Opis

This volume provides a comprehensive description of phospholipid metabolism in brain, activities of phospholipases A₂, and their involvement in neurological disorders. The purpose of this book is to present readers with cutting edge information in a lively manner that is useful not only to student and teachers but also to researchers and physicians.

Spis treści

Phospholipid Metabolism in Brain.- Ether Lipids in Brain.- Phospholipases A2 in Brain.- Roles of Phospholipases A2 in Brain.- Arachidonic Acid and Its Metabolites in Brain.- Docosahexaenoic Acid and Its Metabolites in Brain.- Nonenzymic Metabolites of Arachidonate and Docosahexaenoate in Brain.- Lyso-Glycerophospholipids.- Lysophosphatidic Acid and Its Metabolism in Brain.- Involvement of Phospholipids and Phospholipases A2.- Inhibitors of Phospholipases A2 and Their Use for the Treatment of Neurological Disorders.- Assay Methods for Phospholipase A2 Activities in Brain.- Glycerophospholipids and Phospholipases A2 in Neuropsychiatric Disorders.- Future Perspectives: Metabolic and Functional Aspects of Neural Membrane Glycerophospholipids.

Blurb

Glycerophospholipids in Brain: Phospholipases A₂ in Neurological Disorders
Akhlaq A. Farooqui and Lloyd A. Horrocks

Glycerophospholipids in Brain: Phospholipases A₂ in Neurological Disorders provides a synthesis of material on the metabolism of phospholipids in the brain which has previously only been available in a scattered number of original papers and reviews. Here, the research of over 25 years is collected in one volume from two of the leading researchers in the field— Akhlaq A. Farooqui and Lloyd A. Horrocks

Glycerophospholipids in Brain: Phospholipases A₂ in Neurological Disorders comprehensively describes:

• metabolism in brain of glycerophospholipids, including those containing a vinyl ether group (plasmalogens)
• cutting-edge information on the properties and roles of phospholipases A₂ in the central nervous system
• release by phospholipases A₂ of second messengers (arachidonic acid, docosahexaenoic acid, and lysophospholipid) from neural membrane phospholipids and their neurochemical effects on brain metabolism and function
• involvement of phospholipases A₂ in neurological and neuropsychiatric disorders, and the use of phospholipase A₂ inhibitors for the treatment of diseases associated with altered phospholipid metabolism
• methods for the assays of phospholipases A₂ and their clinical significance

This unique volume will be invaluable not only to those interested in biochemical properties of phospholipases A_2, but also their involvement in neurological disorders. Students will benefit from it as a supplement for a range of neuroscience courses. Clinicians will find it invaluable as well for understanding molecular aspects of neurodegeneration in acute neural trauma (stroke) and neurodegenerative diseases (Alzheimer disease) that are mediated by phospholipases A₂.

The information in Glycerophospholipids in Brain: Phospholipases A₂ in Neurological Disorders is presented in a lively manner that has never been attempted until now in this specialized format. It will be the essential text for the authoritative research in the field.

About the Authors

Akhlaq A. Farooqui and Lloyd A. Horrocks are leaders in the fields of phospholipid metabolism and phospholipases A₂ in brain. They have published cutting edge research on phospholipases A₂ and their involvement in neurological disorders in brain tissue. In collaboration with Dr. Yutaka Hirashima, they have discovered a plasmalogen-selective phospholipase A₂ in brain. They have also studied phospholipids composition of neural membranes and activities of phospholipases A₂ in neural membranes. Lloyd A. Horrocks is the founding editor of Molecular and Chemical Neuropathology and has edited seven books.