Giardia and Giardiasis: Part a Volume 106

ISBN-13: 9780128177204 / Angielski / Twarda / 2019 / 268 str.

Guadalupe Ortega-Pierres

Recenzje

"This is an excellent resource that covers essential information on molecular and cellular biology of Giardia and giardiasis. It will be highly useful for students, researchers, and parasitologists. There are very few books that provide an extensive coverage on molecular and cellular biology of Giardia and giardiasis and this book surely takes a lead." --Doody

Spis treści

1. Unusual proteins in Giardia duodenalis and their role in survival 2. The protein 14-3-3: A functionally versatile molecule in Giardia duodenalis 3. A cytonaut's guide to protein trafficking in Giardia lamblia 4. Giardia duodenalis: Role of secreted molecules as virulent factors in the cytotoxic effect on epithelial cells 5. Recent insights into innate and adaptive immune responses to Giardia 6. Molecular epidemiology of giardiasis from a veterinary perspective

O autorze

Dr. M. Guadalupe Ortega Pierres´ group carries out studies on the protozoan parasite Giardia duodenalis which is a common intestinal parasite in humans worldwide that causes giardiasis. This infection is one of the most frequently diagnosed waterborne diseases and is considered a major public health problem particularly in developing countries.
Her work includes the study of basic aspects of host-pathogen interaction. In particular her group is interested in identifying parasite molecules which are expressed and secreted during the interaction of parasite with epithelial cells such as proteases, VSPs and enolase. Also her group has addressed the analysis of the damage caused by these virulence factors in epithelial cells and at the intestinal epithelium in order to understand at the molecular level the pathogenic mechanisms in experimental giardiasis. These studies will define parasite components involved in epithelial cell damage and these may allow the design of new strategies for the control and prevention of giardiasis both in humans and in animals.
Her group has also approached the study of the mechanisms involved in the induction of resistance to drugs commonly used in the treatment of giardiasis. They have approached this by the generation of resistant G. duodenalis strains and clones to different drugs and these have been used to identified both, mechanisms and molecules that are involved, particularly, in the resistance to albendazole. These studies will allow understanding the processes involved in the induction of
drug resistance in Giardia and will contribute to develop other useful methods for the treatment of the giardiasis.