Ghrelin

ISBN-13: 9781475788419 / Angielski / Miękka / 2013 / 257 str.

Ezio Ghigo

Opis

Ghrelin is a 28-amino acid acylated peptide predominantly produced by the stomach. It displays strong GH-releasing activity mediated by the hypothalamus-pituitary GH secretagogue (GHS)-receptors specific for synthetic GHS. Ghrelin also acts on other central and peripheral receptors and enables other actions including: stimulation of lactotroph and corticotroph secretion; food-intake; gastro-entero-pancreatic functions; metabolic; cardiovascular activity; and anti-proliferative effects. This volume aims to highlight the impact and function of the hormone ghrelin and provide insight to neuroendocrinologies and researchers interested in its molecular and clinical relevance.

Recenzje

`Exemplifying the rapid advance of science, the discovery of GHRELIN a few short years ago has already profoundly influenced our understanding of growth, appetite and nutrition biology as well as clinical insights into obesity, growth and reproductive pathogenesis. Accordingly, the editor, a pioneer in clinical ghrelin investigation, has assembled an expert team of authors who bring cutting edge anExemplifying the rapid advance of science, the discovery of GHRELIN a few short years ago has already profoundly influenced our understanding of growth, appetite and nutrition biology as well as clinical insights into obesity, growth and reproductive pathogenesis. Accordingly, the editor, a pioneer in clinical ghrelin investigation, has assembled an expert team of authors who bring cutting edge and comprehensive basic and clinical knowledge to the reader. This volume will be of interest to endocrinologists, nutritionists, internists, and pediatricians. Clearly, the volume will be of special interest to neurophysiologists, who now find themselves in the midst of a new world of nutritional control! Shlomo Melmed, M.D. Series Editor Endocrine Updatesd comprehensive basic and clinical knowledge to the reader. This volume will be of interest to endocrinologists, nutritionists, internists, and pediatricians. Clearly, the volume will be of special interest to neurophysiologists, who now find themselves in the midst of a new world of nutritional control!'
Shlomo Melmed, M.D., Series Editor "Endocrine Updates"

Spis treści

Contents List of Contributors Preface 1. Historical Milestones; C.Y. Bowers 2. Discovery of Ghrelin, an Endogenous Ligand for the Growth-Hormone Secretagogue Receptor; M. Kojima, H. Hosoda, H. Kaiya and K. Kangawa 3. Known and Unknown Growth Hormone Secretagogue Receptors and their Ligands; G. Muccioli, F. Broglio, E. Tarabra and E. Ghigo 4. Ghrelin: A New Link Between the Neuroendocrine Control of the GH Axis, Food Intake and Sleep; V. Tolle and the INSERM-ATC Nutrition Research Group on Ghrelin 5. Growth Hormone Releasing Activity of Ghrelin; C. Diéguez, F. Cordido, V. Popovic and F.F. Casanueva 6. Non-Growth Hormone Endocrine Actions of Ghrelin; M. Korbonits and A.B. Grossman 7. Ghrelin Food Intake and Energy Balance; M.H. Tschöp, T. Castañeda and U. Pagotto 8. Cardiovascular Activities of Ghrelin and Synthetic GHS; J. Isgaard, I. Johansson and Å. Tivesten 9. Ghrelin: Central Actions and Potential Implications in NeuroDegenerative Diseases; R.G. Smith, Y. Sun, A.R.T. Bailey and A. Paschali 10. Ghrelin and Tumors; M. Papotti, C. Ghè, M. Volante and G. Muccioli 11. Metabolic Actions of Ghrelin; C. Gauna and A.J. van der Lely 12. Gastro-Entero-Pancreatic Actions of Ghrelin; Y. Date, M. Nakazato, K. Kangawa and H. Matsuo 13. A New Interaction to Come: Ghrelin and Steroid Hormones; U. Pagotto, A. Gambineri, V. Vicennati and R. Pasquali 14. Circulating Ghrelin Levels in Pathophysiological Conditions; D.E. Cummings and J. Overduin 15. Ghrelin Measurement: Present and Perspectives; H. Hosoda and K. Kangawa 16. Ghrelin: Implications in Pediatric Endocrinology; S. Bellone, A. Rapa, F. Broglio and G. Bona 17. Ghrelin and its Analogues: Perspectives for a Story of Reverse Pharmacology; E. Ghigo Index