Germfree and Gnotobiotic Animal Models: Background and Applications

ISBN-13: 9780849340086 / Angielski / Twarda / 1996 / 208 str.

Bernard S. Wostmann

Opis

The germfree animal is reared in the laboratory to be bacteria free; its counterpart, the gnotobiotic animal, is exposed to select microorganisms. The need for such an animal model for use in biomedical studies was first expressed by Pasteur in the late 1800s. Subsequent development of germfree and gnotobiotic animals led to an explosion of studies on the effects of microflora and its components on the physiology and metabolism of the host. Germfree and Gnotobiotic Animal Models brings together the most notable points of early and recent studies and gives reference to the most pertinent literature.

Spis treści

Introduction. Early Growth, Body Weight, Reproduction, and Life Span. Anatomy, Morphology, and Function of the Gastrointestinal System. Morphology and Physiology, Endocrinology and Biochemistry. Nutrition. The Chemically Defined Diet. Immunology, Including Radiobiology and Transplantation. Parasitology. Pathology Over the Life Span of the Germfree Rat and the Germfree Mouse. Applications: Past, Present, and Future. Part I. Applications: Past, Present, and Future. Part II. Use of the Gnotobiote in the Study of Disease. Applications: Past, Present, and Future. Part III. The Production of Monoclonal Antibodies and Conclusions. Index.

NTI Copy/Back cover copy

O autorze

Bernard S. Wostmann (University of Notre Dame) (Author)