Genome and Genomics: From Archaea to Eukaryotes

ISBN-13: 9789811507045 / Angielski / Miękka / 2020 / 307 str.

K. V. Chaitanya

Spis treści

PART I: Viral Genomes

1.1 Introduction

1.2 Organization and Structure of Viral genomes

1.3 Viral Genomes

1.4 Double stranded DNA Virus Genomes

1.5 Single stranded DNA Virus Genomes

1.6 RNA virus genomes

1.7 Segmented Viral Genomes

1.8 Multipartite Viral genomes

1.9 Evolution of Viral Genomes

1.10 Conclusions

1.11. References

Part II: Archeal Genomes

2.1 Introduction

2.2 Archaea

2.3 Unique features of archaea

2.4 Archaea and Eukaryotes

2.5 Archaeal genomes

2.5.1 Structure and organization of archaeal genomes

2.6 Plasmids of archaea

2.7 Horizantal Gene Transfer

2.8. Integrase mediated insertion and deletions in archaea

2.9 Genome of methanogenic archeon Methanococcus Jannaschii

2.10 Genome of the hyperthermophilic, sulphate-reducing archaeon, archaeoglobus

fulgidus

2.11 Conclusions

2.12. References

PART III: Bacterial Genomes

3.1 Introduction

3.2 Structure and Organization of Bacterial Genomes

3.3 Genome re-arrangements in Bacteria

3.4 Evolution of bacterial genomes

3.5 Genetic diversity of pathogenic bacteria

3.6 Genome of E.coli

3.7 Whole genome sequencing of pathogenic E.coli O157:H7

3.8 Genome of Mycoplasma genitalium

3.9 Synthetic genome of Mycoplasma genitalium

3.10 Conclusions

3.11 References

Part IV: Organellar Genomes

4.1 Introduction

4.2. Resemblances of Chloroplast and Mitochondria with Bacteria

4.3. Architecture of Organellar Genomes

4.4. Organelle Genome Evolution

4.5 Chloroplast Genomes

4.6 Chloroplast Genome Engineering

4.7 Chloroplast genome of Euglena gracilis

4.8 Mitochondrial genomes

4.9. Structure of Mitochondrial Genomes

4.10. Mutations in the Mitochondrial Genomes and Diseases

4.11 Mitochondrial genome of Neandertal fossils

4.12 Plant Mitochondrial Genome

4.13 Conclusions

4.14. References

Part V: Genomes of Eukaryotes

5.1. Introduction

5.2 Organization of nuclear genome in eukaryotic organisms

5.3 Complexity of the Eukaryotic Genomes

5.4 Yeast Genome

5.5 Genome of C. elegans

5.6. Genome of Drosophila melagastor

5.7. Genome of Arabidopsis thaliana

5.8 Genome of soybean

5.9. rice Genome

5.10 Human genome

5.11 Conclusions

5.12 References

Part VI: Genome sequencing and Annotation

6.1 Introduction

6.2 First Generation DNA sequencing

6.3. Second Generation DNA sequencing

6.4. Third Generation DNA sequencing

6.5. Sequencing of Fungal Genomes

6.6. Sequencing of Plant genomes

6.7. Sequencing of Animal Genomes

6.8. Whole Genome Sequencing

6.9. Genome Sequencing by Mass Spectrometry

6.10. Mapping of Genomes

6.11. Genome Assembly

6.12. Scaffolding

6.13. Finishing

6.14. Genome Annotation

6.15. Applications of Next Generation Sequencing Systems

6.16. Conclusions

6.17. References

Part VII: Other Omics Integrated into Biosciences

7.1. Introduction

7.2. Transcriptomics

7.3. Proteomics

7.4. Metabolomics

7.5. Exposomics

7.6. Connectomics

7.7. Microbiomics

7.8. Conclusions

7.9. References

Part VIII: Application of genomics

8.1 Introduction

8.2 Applications of genomics in agriculture

8.3. Applications of genomics in genetic testing and molecular diagnostics

8.4. Epigenetics and epigenomics

8.5.Genomic medicine

8.6. Genomics and cancer therapy

8.7. Cytogeenomics

8.8. Microarrays

8.9.Comparitive genomics

8.10. Conclusions

8.11. References

O autorze

Dr. K.V.Chaitanya is an Associate Professor at the Department of Biotechnology, GITAM University, Visakhapatnam. He completed his Ph.D. in Life Sciences at Pondicherry University, and then received a fellowship from DBT to pursue post-doctoral studies at the Indian Institute of Science, Bengaluru. He has over 15 years of experience in research in the fields of genomics, molecular biology and plant biotechnology. He has worked in various capacities in internationally respected academic and research institutes and has published a number of articles in leading international journals. He has published one book on cell and molecular biology and has filed five patents. Dr. Chaitanya has received numerous academic awards and fellowships.

 

Blurb

This book provides a detailed and  up-to-dated information on the genomes belonging to three major life forms on Earth – archaea, prokaryotes and eukaryotes. Each section describes about the genome of a specific group of organisms, such as viruses, archaea, bacteria, eukaryotes and organellar genomes. Individual chapters provide details of their organization, structure, evolution, sequencing strategies and functions. Further, this book discusses the technologies that are applied for genome sequencing; assembly, annotation and gene prediction. Other topics include the genomes of important model organisms, mitochondria genome of Neanderthal fossil, etc.  This book also examines the evolution of chloroplast and mitochondria genomes by comparing with bacteria, addresses the diseases that occur in humans due to the mutations in mitochondrial genome, gene therapy and engineering of chloroplast and mitochondrial genomes. Lastly, it features an overview of the role of proteomics, exposomics, connectomics, metabolomics, and microbiomics.

This book is a fascinating read for students, lecturers and researchers in the field of genetics, genomics, microbiology and life sciences.