1. From Mendelian Genetics to 4D Genomics. No significant changes; adding new references 2. Genes and Genomes Represent Different Biological Entities 3. Genome Chaos and Cellular Macroevolution: How Evolutionary Cytogenetics Unravels the Mystery of Cancer. Replace four Figures with modifications 4. Karyotype Coding and Fuzzy Inheritance: The Genomic Basis of Bio-information and Heterogeneity 5. Why Sex? Genome Reinterpretation Dethrones the Queen 6. Breaking the Genome Constraint: The Mechanism of Macroevolution 7. The Creation and Maintenance of System Information for Complexity and Biodiversity 8. Searching for an Information-Based and Historically Contingent Evolutionary Theory 9. The Genome Architecture Theory: A New Framework 10. The Rationale and Challenges for Molecular Medicine