Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine

ISBN-13: 9780128136355 / Angielski / Miękka / 2019 / 556 str.

Henry H. Heng

Spis treści

1. From Mendelian Genetics to 4D-Genomics2. Genes and Genomes Represent Different Biological Entities 3. Genome Chaos and Macro-cellular Evolution: How Evolutionary Cytogenetics Unravels the Mystery of Cancer4. Chromosomal Coding and Fuzzy Inheritance5. Why sex? Genome Re-interpretation Dethrones the Queen6. Breaking the Genome Constraint: The Mechanism of Macro-evolution7. The Genome Theory: A New Framework8. The Rationale and Challenges for Precision Medicine

O autorze

Dr. Henry H. Heng has coauthored over 200 publications and serves on the editorial boards of six international, peer-reviewed journals. Using single-cell analysis of in vitro and in vivo models, Dr. Heng's group has illustrated the evolutionary dynamics of cancer progression by directly observing evolution in action. These experiments demonstrated that stochastic punctuated genome alterations rather than stepwise gene mutations are the driving force of cancer evolution. By applying this concept to organismal evolution, he discovered that the main function of sex is to reduce genetic diversity at the genome level in order to preserve the information and genome-defined species identity. Heng has introduced the Genome Architecture Theory, a new genome-based conceptual framework of genomics and evolution.