Genetics of Colorectal Cancer

ISBN-13: 9781441918659 / Angielski / Miękka / 2010 / 309 str.

John D. Potter; Noralane M. Lindor

Opis

Genetic susceptibility refers to how variations in a person s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology. "

Spis treści

Section One – Epidemiology and Models of Colorectal Cancer Chapter 1. Colorectal Cancer – Epidemiology. John D. Potter and David Hunter. Chapter 2. Mouse Models of Intestinal Cancer. Erin M. Perchiniak and Joanna Groden. Section Two – Pathways to Colorectal Cancer Chapter 3. The Chromosomal Instability Pathway and APC Gene Mutation in Colorectal Cancer. Robert Gryfe and Steven Gallinger. Chapter 4. DNA Methylation in Colorectal Cancer: multiple facets of tumorigenesis. Joanne P. Young and Peter W. Laird. Chapter 5. Pathways and Pathology. Jeremy R Jass Section Three – Germline Susceptibility – Mendelian and Other Syndromes Chapter 6. Familial Adenomatous Polyposis. Julian A. Sanchez, Graham Casey, and James M. Church. Chapter 7. DNA Mismatch Repair and the Lynch Syndrome. Brittany C. Thomas, Matthew J. Ferber, and Noralane M. Lindor. Chapter 8. Other Syndromes Chapter 8.1. MUTYH-Associated Polyposis (MAP). Spring Holter and Steven Gallinger. Chapter 8.2. Familial Colorectal Cancer Type X. Noralane M Lindor. Chapter 8.3. Families with Serrated Neoplasia of the Colon. Joanne Young. Chapter 8.4. Peutz-Jeghers Syndrome. Douglas L. Riegert-Johnson and Lisa A. Boardman. Chapter 8.5. Juvenile Polyposis. Kara A. Mensink, Jeremy R. Jass, and Noralane M. Lindor. Chapter 8.6. BLM mutation and Colorectal Cancer Susceptibility. Beatriz Russell and Joanna Groden Chapter 8.7. The Role of p53 in Colorectal Cancer. Serena Masciari and Sapna Syngal. Chapter 8.8. Chromosomes 8q24 and 9p24: Associations with Colorectal Cancer. John D Potter Section Four – Germline Susceptibility – Gene-Environment Interactions Chapter 9. Genetic Variability in Folate Mediated One-Carbon Metabolism and Risk of ColorectalNeoplasia. Amy Y. Liu and Cornelia M. Ulrich. Chapter 10. Genetic Variability in NSAID targets and NSAID-metabolizing Enzymes and Colorectal Neoplasia. Elizabeth M. Poole, James T. Cross, John D. Potter, and Cornelia M. Ulrich. Chapter 11. The Role of Chemical Carcinogens and their Biotransformation in Colorectal Cancer. Loïc Le Marchand Chapter 12. Calcium and Vitamin D in Colorectal Cancer. Roberd M. Bostick, Michael Goodman, and Eduard Sidelnikov

Blurb

The last 20 years have seen a remarkable increase in knowledge of the etiology of colorectal cancer. At least three aspects are much clearer. First, known environmental agents and behaviors have been identified that increase risk (for example, diets high in meat, obesity, and smoking ) or decrease risk (for example, diets high in plant foods, aspirin, and physical activity) of colorectal cancer. Second, germline mutations in specific genes have been identified for the major inherited syndromes involving colorectal cancer (FAP, Lynch Syndrome, Juvenile Polyposis, MYH-Associated Polyposis, Li-Fraumeni Syndrome) as have variants of genes that modify the risk associated with the known environmental agents. Third, the specific tissue, cellular, and molecular disturbances that characterize the progression to different subtypes of colorectal cancer have been recently described. Genetics of Colorectal Cancer provides the most up-to-date information in each of these areas.