Genetically Engineered Mice Handbook [With Full Color Images]

ISBN-13: 9780849322204 / Angielski / Twarda / 2005 / 336 str.

John P. Sundberg; Tsutomu Ichiki

Opis

While mice have always been highly popular laboratory subjects, their suitability for genetic engineering has solidified their position as today's lab animal model of choice. However, their increased use in genetic studies has created a demand for input on phenotyping that is not always easily met.
To improve the flow of information on the pathology of mice with spontaneous or genetically engineered mutations, prominent researchers organized a series of meetings. Recognizing other needs, the organizers gradually broadened their focus, until finally they expanded to provide an overview of the entire field of genetically engineered models.
The Genetically Engineered Mice Handbook is an extension of those meetings. It offers an introduction for those entering into this area of research, while also serving as a resource for those presently employing mice as laboratory models. Highly comprehensive, this volume covers pertinent aspects of genetically engineered mice, including the use of models for developmental biology and the monitoring of laboratory colonies. With contributions from nearly five-dozen leading researchers, the text presents systematic approaches for analyzing mutant mice for specific medical applications, details a variety of methods for creating mutants and includes information that is particularly hard to access dealing with legal responsibilities.
This essential reference examines commonly used traditional, as well as emerging, technologies
To address the purpose of the original meeting, the Genetically Engineered Mice Handbook directs researchers to the best public websites, and offers instruction on how to use them. In the past, as their work dictated, researchers would seek out experts on particular organ systems. Now groups of experts work together to generate these websites, providing the latest data as well as discussions over points of debate. These sites do not eliminate the need for a trained pathologist, but they do provide reference materials for those lacking expertise in particular anatomic structures. They also offer much greater numbers of examples than are available in print, from which biomedical researchers can draw.

Spis treści

Genetically Engineered Mice: Past, Present, and Future: John P. Sundberg, Tsutomu Ichiki, Jerrold M. Ward, and Björn RozellSharing Reseach Tools: The Laboratory Mouse: David EinhornManaging Success: Mutant Mouse Repositories: Stephen F. Rockwood, Martin D. Fray, and Naomi NakagataMouse Genome Informatics: Database Access to Integrated Phenotype Data: Carroll-Ann W. Goldsmith, Martin Ringwald, John P. Sundberg, Carol J. Bult, and Janan T. EppigGenetic Resouce Databases in Japan: Yukiko YamazakiComputational Pathology: Challenges in the Informatics of Phenotype Description in Mutant Mice: Paul N. Schofield, Jonathan B. L. Bard, Björn Rozell, and John P. SundbergBiological Methods for Archiving and MaintainingMutant Laboratory Mice: Martin D. Fray, Peter H. Glenister, Steven Rockwood, Takehito Kaneko, and Naomi NakagataMouse Genetic Resources without Germ Cells: Somatic Cell Nuclear Transfer and ES Technology: Teruhiko WakayamaThe Present Status of Somatic Cell Cloning: Atsuo Ogura, Kimiko Inoue, Narumi Ogonuki, and Hiromi MikiExchangeable Gene Trapping: Kimi ArakiGenetic Monitoring of Mice: Hideki KatohMicrobiological Monitoring of Laboratory Mice: James R. FaheyEffect of Intestinal Flora on Phenotype: Seiko Narushima and Kikuji ItohHelicobacter pylori and Stomach Cancer: Masae Tatematsu, Tetsuya Tsukamoto, and Tsutomu MizoshitaProfessional Use of Mutant Laboratory Mice in Research: John P. Sundberg and Carol J. BultPhenotyping Postpartum Mutant Laboratory Mice and Determining Their Value for Human Diseaes: John P. Sundberg and Tsutomu IchikiCommon Diseases Found in Inbred Strains of Laboratory Mice: John P. Sundberg and Tsutomu IchikiColon Cancer and Polyposis Models: Makoto Mark TaketoPhenotypic Analysis of Mice with Steroid Deficiency: Noomen Ben El Hadj, Meng-Chun Hu, Hsueh-Ping Chu, Leo Chi-Kuang Wang, and Bon-chu ChungExternal Genitalia Development: A Model System to Study Organogenesis: K. Suzuki, H. Nishida, S. Ohta, Y. Satoh, Y. Xu, Y. Zhang, Y. Wada, Y. Ogino, N. Nakagata, T. Ohba, and G. YamadaGenetic Approaches to Investigate Retinoic Acid Functions in Mouse Development: Pascal Dollé, Karen Niederreither, Julien Vermot, VanessaRibes, Jabier Gallego Llamas, and Isabelle Le RouxMouse Models for Developmental Biology: Functional Analysis of Ror and Wnt Signaling: Isao Oishi, Akinori Yoda, Shuichi Kani, and Yasuhiro MinamiIndex

O autorze

John P. Sundberg, Tsutomu Ichiki