Genes, Oncogenes, and Hormones: Advances in Cellular and Molecular Biology of Breast Cancer

ISBN-13: 9780792317487 / Angielski / Twarda / 1992 / 446 str.

Robert B. Dickson; Robert B. Dickson; Marc E. Lippman

Opis

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current di agnosis, staging, markers, all forms of treatment modalities, basic biology, and more."

Spis treści

I. The Progression of Node-Negative to -Positive Breast Cancer.- 1. Prognostic Factors in Axillary Node-Negative Breast Cancer.- 2. Role of Type IV Collagenases in Human Breast Cancer.- II. Suppressor Genes and Negative Growth Factors.- 3. Suppressor Genes in Breast Cancer: An Overview.- 4. The Role of the Retinoblastoma Gene in Breast Cancer Development.- 5. Mammary Derived Growth Inhibitor (MDGI).- 6. Roles for Transforming Growth Factors-? in the Genesis, Prevention, and Treatment of Breast Cancer.- III. Oncogenes and Stimulatory Growth Factors.- 7. Mechanisms Involving an Expanding erbB/EGF Receptor Family of Tyrosine Kinases in Human Neoplasia..- 8. c-erbB2 Amplification and Overexpression in Human Tumors.- 9. Clinical Significance of c-erbB2B2 Protein Overexpression.- Anti-p185HER2 Monoclonal Antibodies: Biological Properties and Potential for Immunotherapy193.- 11. A Chimeric EGFR/neu Receptor in Studies of neu Function.- 12. Involvement of Protein Kinase C in the Growth Regulation of Human Breast Cancer Cells.- 13. Tyrosine Kinase Receptor — Nuclear Protooncogene Interactions in Breast Cancer.- IV. Steroid Hormone Receptors.- 14. Characterization and Regulation of Estrogen and Progesterone Receptors in Breast Cancer.- 15. Estrogen and Progesterone Receptor Structure and Action in Breast Cancer Cells.- 16. Progesterone Receptors in Breast Cancer.- V. Differentiation and Function of Epithelium and Stroma in the Breast.- 17. Intermediate Filament Protein Expression in Normal and Malignant Human Mammary Epithelial Cells.- 18. Casein Gene Expression: From Transfection to Transgenics.- 19. The Whey Acidic Protein.- 20. Stromal-Epithelial Interactions in Breast Cancer.