Genes, Development and Cancer: The Life and Work of Edward B. Lewis

ISBN-13: 9781402063435 / Angielski / Miękka / 2007 / 597 str.

Howard D. Lipshitz

Opis

Edward B. Lewis' science is the bridge linking experimental genetics as conducted in the first half of the twentieth century, and the powerful molecular genetic approaches that revolutionized the field in its last quarter. His Nobel Prize winning studies founded the field of developmental genetics and laid the groundwork for our current understanding of the universal, evolutionarily conserved strategies controlling animal development. A lesser-known aspect of Lewis' canon is the pioneering studies he carried out on ionizing radiation and human cancer. In doing so, he was propelled into a public storm over nuclear weapons testing policy. For the first time Lewis' key publications in the fields of genetics, developmental biology, radiation and cancer are compiled within one volume. Howard Lipshitz, a close colleague during the last 20 years of Lewis' life, provides commentaries on the papers, placing them in their scientific and historical context and, throughout, giving insight into Lewis' approach to science and the motivations that drove Lewis' choice of subject matter. This book will be invaluable to a wide audience of professionals in the life and biomedical sciences; including geneticists, developmental biologists, molecular biologists, radiation biologists and cancer researchers. It provides source material for advanced undergraduate and graduate level courses in genetics, developmental biology, radiation and cancer. In addition, historians of science will find it to be a valuable resource both because it contains original research publications and because of the illuminating commentary. The Second Edition has been expanded with new material and the commentaries have been updated. Comments on the First Edition: A great book that is of interest to many geneticists, developmental biologists, and historians of science. (Prof. Matthew P. Scott - Stanford University) A wonderful compendium of Lewis' papers. Lipshitz has done an outstanding job of summarizing and in many cases clarifying Lewis' writings. (Prof. James F. Crow, University of Wisconsin, Madison) A very valuable reference for those studying developmental biology, radiation and cancer. (Dr. Susan Celniker, Lawrence Berkeley National Laboratory, Berkeley, California) An excellent resource for understanding the emergence of developmental genetics. (Prof. Siegfried Roth, University of Koln, Germany) Since the best way to become a good scientist is to understand how scientific ideas have been born and have developed, this book should be read by all graduate students in the areas of genetics, development and evolution. (Prof. Markus Noll, University of Zurich, Switzerland)"

Recenzje

"A great book that is of interest to many geneticists, developmental biologists, and historians of science." (Prof. Matthew P. Scott - Stanford University)

"A wonderful compendium of Lewis' papers. Lipshitz has done an outstanding job of summarizing - and in many cases clarifying - Lewis' writings." (Prof. James F. Crow, University of Wisconsin, Madison)

"A very valuable reference for those studying developmental biology, radiation and cancer." (Dr. Susan Celniker, Lawrence Berkeley National Laboratory, Berkeley, California)

"An excellent resource for understanding the emergence of developmental genetics." (Prof. Siegfried Roth, University of Köln, Germany)

"Since the best way to become a good scientist is to understand how scientific ideas have been born and have developed, this book should be read by all graduate students in the areas of genetics, development and evolution." (Prof. Markus Noll, University of Zurich, Switzerland)

Spis treści

Genes.- Star-Recessive, a Spontaneous Mutation in Drosophila Melanogaster.- Another Case of Unequal Crossing Over in Drosophila Melanogaster.- The Relation of Repeats to Position Effect in Drosophila Melanogaster.- The pseudoallelism of white and apricot in Drosophila melanogaster.- Pseudoallelism and Gene Evolution.- The Theory and Application of a New Method of Detecting Chromosomal Rearrangements in Drosophila Melanogaster.- Some Aspects of Position Pseudoallelism.- Genes and Gene Complexes.- Genes and Development.- Genes and Developmental Pathways.- A Gene Complex Controlling Segmentation in Drosophila.- Genetic Control of Body Segment Differentiation in Drosophila.- Control of Body Segment Differentiation in Drosophila by the Bithorax Gene Complex.- Regulation of the Genes of the Bithorax Complex in Drosophila.- Molecules and Development.- Molecular Genetics of the Bithorax Complex in Drosophila Melanogaster.- The Abdominal Region of the Bithorax Complex.- Transabdominal, A Dominant Mutant of the Bithorax Complex, Produces a Sexually Dimorphic Segmental Transformation in Drosophila.- Molecular Basis of Transabdominal—A Sexually Dimorphic Mutant of the Bithorax Complex of Drosophila.- Sequence Analysis of the Cis-Regulatory Regions of the Bithorax Complex of Drosophila.- Splits in Fruitfly Hox Gene Complexes.- Evolution of the Homeobox Complex in the Diptera.- Radiation and Cancer.- Leukemia and Ionizing Radiation.- Thyroid radiation doses from fallout.- Leukemia, multiple myeloma, and aplastic anemia in american radiologists.- Ionizing Radiation and Tumor Production.- Leukemia, Radiation, and Hyperthyroidism.- Analysis of Lung Tumor Mortality in the Battelle Beagle Lifespan Experiment.- Ionizing Radiation, Cancer Induction, and Radioactive Fallout.- Historical perspectives.- Homeosis: the first 100 years.- Remembering Sturtevant.- C. B. Bridges' Repeat Hypothesis and the Nature of the Gene.- Did Demerec Discover Intragenic Recombination in 1928?.- The Bithorax Complex: The First Fifty Years.