Gene Vaccines

ISBN-13: 9783709119297 / Angielski / Miękka / 2016 / 330 str.

Josef Thalhamer;Richard Weiss;Sandra Scheiblhofer

Opis

This up-to-date volume provides an overview of the "world of naked gene vaccines", namely DNA and RNA vaccines. Topics include general mechanisms, inherent immunostimulatory properties, the vast potential to modulate immune responses, and more.

Spis treści

Preface.- 1 General mechanisms of gene vaccines.- 2 Strategies to Improve DNA Vaccine Potency: HPV-associated Cervical Cancer as a Model System.- 3 Immune-activating mechanisms of replicase-based DNA and RNA vaccines and their role in immune-apoptosis.- 4 Cytokine genes as molecular adjuvants for DNA vaccines.- 5 Pharmaceutical non-viral formulations for gene vaccines.- 6 Rational design of formulated DNA vaccines: the DermaVir approach.- 7 In vivo electroporation.- 8 Electroporation-based Trigrid™ delivery system (TDS) for DNA vaccine administration.- 9 Prime Boost Regimens for Enhancing Immunity: Magnitude, Quality of Mucosal and Systemic Gene Vaccines.- 10 Intranodal genetic immunization.- 11 Immunotherapy of cancer with RNA vaccines.- 12 DNA and RNA vaccines for prophylactic and therapeutic treatment of type I allergy.- 13 Approved veterinary vaccines – paving the way to products for human use.- 14 Current status of regulations for DNA vaccines.- 15 State of the art production of antibiotic resistance-free plasmid DNA.- 16 Industrial Manufacturing of Plasmid-DNA Products for Gene Vaccination and Therapy.