Gene Therapy in Inflammatory Diseases

ISBN-13: 9783034895842 / Angielski / Miękka / 2012 / 260 str.

Christopher H. Evans;Paul D. Robbins

Opis

Gene therapy for inflammatory diseases is a new, burgeoning field of medicine. Edited by the undisputed pioneers of this area of research, this volume is the first devoted to its topic. It contains thirteen chapters, each written by leaders in their respective fields, that summarize the state of the art in developing novel, gene based treatments for inflammatory diseases. As well as providing an introduction to the basic concepts of gene therapy and the use of naked DNA approaches, the book describes the advances that have been made in applying them to arthritis, lupus, multiple sclerosis, diabetes, Sjogrens syndrome and transplantation.One chapter is devoted to discussing the first human clinical trials that apply gene therapy to the treatment of an inflammatory disease. As well as providing novel therapeutic approaches, gene therapy facilitates the development of new and improved animal models of disease; a chapter describing these advances is also included. As an up-to-date, timely book written by th

Spis treści

List of Contributors. Preface. Christopher H. Evans, Paul D. Robbins: Gene therapy for inflammatory diseases - basic concepts. Sergei S. Makarov: Gene therapy for rheumatoid arthritis pre-clinical studies. Thomas Pap, Ulf Müller-Ladner, Klaus M. Hummel, Renate E. Gay and Steffen Gay: Cartilage erosion in rheumatoid arthritis studies in scid mouse model. Thomas S. Muzzonigro, Richard Kang, J. Reinecke, Peter Wehling, M.C. Wasko and James H. Herndon: Gene therapy for rheumatoid arthritis: clinical studies. Alistair J. Ramsay, Simon P. Hogan, Paul S. Foster and Yelin Xiong: Cytokine gene therapy of allergic airways inflammation. Philip C. Fox and Brian C. O'Connell: Gene therapy for inflammatory diseases of the salivary glands. Huang-Ge Zhang, Martin Fleck, Hui-Chen Hsu, Carl K. Edwards III, David T. Curiel, Tong Zhou and John D. Mountz: Gene therapy for management of lupus: correction of Fas and Fas ligand-induced apoptosis in murine disease - therapeutic rational and strategies. Michael K. Shaw, Richard DalCanto and C. Garrison Fathman: Gene therapy for Multiple Sclerosis. Nick Giannoukakis, Massimo Trucco and Paul D. Robbins: Gene therapy for type I Diabetes Mellitus. Jonathan S. Bromberg, Lisa A. DeBruyne, Randall S. Sung and Lihui Qin: Gene transfer to facilitate ransplantation. A. Paul Godillot, Michael Madaio, David B. Weiner and William V. Williams: DNA vaccination as an anti-inflammatory strategy. Masayuki Miyata, Yukio Sato and Reiji Kasukawa: Naked DNA as a gene delivery vehicle in inflammatory diseases. Steven C. Ghivizzani, Eric R. Lechman, Daniel Jaffurs, Zhibao Mi, Richard Kang, Thomas Muzzonigro, Christopher H. Evans and Paul D. Robbins: Animal models of arthritis generated by gene transfer.

O autorze

Gene therapy for inflammatory diseases is a new , burgeoning field of
medicine. As an up-to-date, timely book written by the leaders in the
field, this volume will appeal to both medical and graduate students,
medical reseachers, members of the biotechnology community, physicians
and all those interested in this latest frontier of molecular medicine.