Gene Therapy, an Issue of Hematology/Oncology Clinics of North America: Volume 31-5

ISBN-13: 9780323546683 / Angielski / Twarda / 2017

Daniel E. Bauer; Donald B. Kohn

Spis treści

Hematology/Oncology Clinics

Gene Therapy

Preface: Gene Therapy

Historical Perspective on the Current Renaissance for Hematopoietic Stem Cell Gene Therapy

Integrating Vectors for Gene Therapy and Clonal Tracking of Engineered Hematopoiesis

Nonintegrating Gene Therapy Vectors

In Vivo Hematopoietic Stem Cell Transduction

Therapeutic Gene Editing Safety and Specificity

Gene Editing: Regulatory and Translation to Clinic

Opening Marrow Niches in Patients Undergoing Autologous Hematopoietic Stem Cell Gene Therapy

Gene Therapy Approaches to Immunodeficiency

Gene Therapy Approaches to Hemoglobinopathies

Gene Therapy for Hemophilia

Hematopoietic Gene Therapies for Metabolic and Neurologic Diseases

Gene Therapy Approaches to Human Immunodeficiency Virus and Other Infectious Diseases

Hematopoietic Stem Cell Approaches to Cancer

Gene Modified T Cell Therapies for Hematological Malignancies