Gene Delivery and Therapy for Neurological Disorders

ISBN-13: 9781493923052 / Angielski / Twarda / 2015 / 359 str.

Xuenong Bo; Joost Verhaagen

Opis

This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors' laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson's and Alzheimer's diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work. Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab. Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders.

Spis treści

1. Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System

            Pádraig J. Mulcahy, Christopher Binny, Bartosz Muszynski, Evangelia Karyka, and Mimoun Azzouz

 

2. Lentiviral Vectors for Gene Delivery to the Nervous System

            Ioanna Eleftheriadou and Nicholas D. Mazarakis

 

3. Gene Therapy for Parkinson’s Disease: AAV-5-Mediated Delivery of Glial Cell Line-Derived Neurotrophic Factor (GDNF)

            Bas Blits, Deniz Kirik, Harald Petry, and Stephen Hermening

 

4. Gene Delivery and Gene Therapy for Alzheimer’s Disease

            Maya Woodbury, Tomomi Kiyota, and Tsuneya Ikezu

 

5. Gene Therapy for Huntington’s Disease

            Angela Wu, Dahna M. Fong, and Deborah Young

 

6. Gene Therapy Approaches to Promoting Axonal Regeneration After Spinal Cord Injury

            Xuenong Bo and Yi Zhang

 

7. Gene Delivery to Neurons of the Dorsal Root Ganglia Using Adeno-Associated Viral Vectors

            Nitish D. Fagoe, Ruben Eggers, Joost Verhaagen, and Matthew R.J. Mason

 

8. Targeted Gene Therapy for Ischemic Stroke

            Fanxia Shen and Hua Su

 

9. Adeno-Associated Viral Gene Therapy for Retinal Disorders

            Samantha R. de Silva, Michelle E. McClements, Mark W. Hankins, and Robert E. MacLaren

 

10. Gene Therapy for Epilepsies

            En-Ju D. Lin and Matthew J. During

 

11. AAV Gene Therapy Strategies for Lysosomal Storage Disorders with Central Nervous System Involvement

            Diane Golebiowski, Allison M. Bradbury, Churl-Su Kwon, Imramsjah M.J. van der Bom, Lorelei Stoica, Aime K. Johnson, Diane U. Wilson, Heather L. Gray-Edwards, Judith A. Hudson, Jacob A. Johnson, Ashley N. Randle, Brian K. Whitlock, James L. Sartin, Anna Luisa Kühn, Matthew Gounis, Wael Asaad, Douglas R. Martin, and Miguel Sena-Esteves

 

12. Gene Therapy in Spinal Muscular Atrophy (SMA) Models Using Intracerebroventricular Injection into Neonatal Mice

            Monir Shababi, Erkan Y. Osman, and Christian L. Lorson

 

13. Gene Therapy for Chronic Pain: How to Manipulate and Unravel Pain Control Circuits from the Brain?

            Isabel Martins and Isaura Tavares

 

14. Gene Therapy Approaches Using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models

            John Lynes, Carl Koschmann, Mia Wibowo, Vandana Saxena, Marianela Candolfi, Mariela A. Moreno Ayala, Maria G. Castro, and Pedro R. Lowenstein