Gene-Based Therapies for Cancer

ISBN-13: 9781461426349 / Angielski / Miękka / 2012 / 278 str.

Jack A. Roth

Opis

Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers. Translational gene therapy approaches are emphasized. Chapters include discussions of specific gene delivery technologies as well as their application to various cancers with extensive discussions of ongoing clinical trials. This information should be useful to both students, fellows, and experienced scientists with an interest in this rapidly developing area.

Spis treści

Gene-based Therapies for Cancer 1. RNAi: A New Paradigm in Cancer Gene Therapy. Edna M. Mora, Selanere L. Mangala, Gabriel Lopez-Berestein, Anil K. Sood 2. Gene-based Therapy for Cancer: Brain tumors. Hong Jiang, Juan Fueyo 3. Gene Therapy of Prostate Cancer. Svend O. Freytag, Hans Stricker, Benjamin Movsas, Mohamed Elshaikh, Ibrahim Aref, Kenneth Barton, Stephen Brown, Farzan Siddiqui, Mei Lu, Jae Ho Kim 4. Si RNA vs shRNA for Personalized Cancer Therapy: Mechanisms and Applications. John S. Vorhies, Donald D. Rao, Neil Senzer, John Nemunaitis 5. Tumor Suppressor Gene Therapy. Jack A. Roth, John Nemunaitis, Lin Ji, Rajagopal Ramesh 6. Targeted Oncolytic Adenovirus for Human Cancer Therapy. Toshiyoshi Fujiwara 7. Gene Therapy for Malignant Pleural Mesothelioma. Edmund K. Moon, Sunil Singhal, Andrew R. Haas, Daniel H. Sterman, Steven M. Albelda 8. Mesenchymal Stem/Stromal Cells (MSC) as Cellular Vehicles for Tumor Targeting. Frank Marini, Matus Studeny, Jennifer Dembinski, Shannon Kidd, Erika Spaeth, Zhizong Zeng, Xiaoyang Li, Ann Klopp, Fredrick Lang, Brett Hall, Michael Andreeff 9. Retargeting Adenovirus for Cancer Gene Therapy. Erin E. Thacker, David T. Curiel 10. Lentiviruses – Vectors for Cancer Gene Therapy. Yuan Lin, Amar Desai, Stan Gerson 11. Interleukin-24 Gene Therapy for Melanoma. Nancy Poindexter, Rajagopal Ramesh, Suhendan Ekmekcioglu, Julie Ellerhorst, Kevin Kim, Elizabeth A. Grimm 12. Herpes Simplex Virus 1 for Cancer Therapy. Richard L. Price, Balveen Kaur, E. Antonio Chiocca 13. Telomerase as a Target for Cancer Therapeutics. Jerry W. Shay 14. Gene Therapy for Sarcoma. Keila E. Torres, Raphael E. Pollock

Blurb

Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers. Translational gene therapy approaches are emphasized. Chapters include discussions of specific gene delivery technologies as well as their application to various cancers with extensive discussions of ongoing clinical trials. This information should be useful to students, fellows, clinical investigators, and experienced scientists with an interest in this rapidly developing area.