1. Historical perspective of Gallstone 2. Comparative study of gallstone with respect to urinary stone and kidney stone Gallstone Formation 3. Role of the gallbladder in our metabolism and Immune system 4. Factors prevailing for gallstone formation 5. Role of liver in gallstone formation 6. The molecular aspect of gallstone formation Association of microflora with gallstone 7. Relation of the microflora of oral cavity and gall bladder 8. Microbial role in gallstone formation Gallstone Derived diseases 9. Gallstone: A factor for Acute pancreatitis 10. Gallstone: A lead factor for gallstone cancer Diagnosis 11. Diagnostic tools for gallstone Treatment Process 12. Role of Probiotics in gallstone treatment 13. Chemical and Herbal treatment for gallstone treatment 14. Artificial Intelligence and Gallstone