Gallbladder Cancer: Current Treatment Options

ISBN-13: 9789811964411 / Angielski / Twarda / 2023 / 349 str.

Vijay Kumar Shukla; Manoj Pandey; Ruhi Dixit

Opis

The book discusses the recent progress in understanding the therapeutic targets for gallbladder cancer to provide opportunities for research and for developing innovative strategies that may enhance the benefit of conventional chemotherapy. The book focuses on identifying candidate molecules and the overall status of the targeted therapies available for gallbladder cancer, as there is an urgent need to discover new molecular targets that can guide the emergence of new treatment strategies to improve patient outcomes and act as biomarkers for the early detection of diseases. Recently, new treatment therapeutics targets for gallbladder cancer patients have been identified and the field is evolving rapidly. The book is relevant for the clinical researcher, surgeon, scientist and academician.

Spis treści

Section I:Surgical Management, Adjuvant Chemotherapy and Palliative Chemotherapy in gallbladder cancer

Ch1. Surgical Management of gallbladder cancer patients
Ch2. Chemotherapy treatment for gallbladder cancer
Ch.3 Adjuvant therapy for the gallbladder cancer treatment
Ch4. Neo-adjuvant chemotherapy in the gallbladder cancer treatment
Ch5. Radiotherapy for locally advanced or metastatic gallbladder cancer

Section II: Targeted Therapies in gallbladder cancer

Ch6. Advanced gallbladder cancer treatment intends to target particular molecular pathways
Ch7. MicroRNA and its significance for the treatment of gallbladder cancer patients
Ch8. Long Non-coding RNAs of gallbladder cancer as developing molecular therapeutics
Ch9. HER2/neu therapy for gallbladder cancer treatment
Ch10. Targeting the EGFR pathways in carcinomas of the gallbladder treatment
Ch11. Anti-egfr therapy as a therapeutic option for galbladder cancer patients
Ch12. Targeting MAPK and mTOR pathways: a potent therapeutic for gallbladder cancer
Ch13. Galectin-9: a therapeutic agent for gallbladder cancer treatment

Section III: Clinical trials in gallbladder cancer treatment

Ch14. Effect of combination of gemcitabine and oxaliplatin with panitumum as first-line therapy for KRAS wild-type gallbladder cancer
Ch15. Effect of ONO-7579in antitumor efficacy against gallbladder cancer
Ch16. Study on the effect of sorafenib (SWOG 0514) in patients having metastatic gallbladder cancer
Ch17. A phase II study on the effect of gemcitabine and oxliplatin or gemcitabine and cisplatin in gallbladder cancer patients

O autorze

Dr. Vijay Kumar Shukla is Rector, Banaras Hindu University and Professor in the Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India. Dr. Shukla is internationally known for his research on gallbladder cancer and wound healing. He had been the visiting Professor at reputed international universities/medical schools. He has been honored with several national and international awards, including the Life Time Achievement Award at the World Union of Wound Healing Societies in Toronto, Canada, in 2008, for his exemplary work in wound healing and research. He was awarded the Fellow of the College of Wound Care Specialist (FCWCS), Malaysia, in 2017 and a fellowship of the National Academy of Medical Sciences in 2007.

In his illustrious career, Prof. Shukla has been the President of the Indian Society of Wound Management, Member of the ICMR task force on gallbladder cancer, Examiner and Inspector of the National Board of Examination, Vice-president, Hernia Society of India, Executive member, Association of Colon and Rectal Surgeons of India, Governing Council Member of ASI, Member, Independent Innovators Expert panel of Ministry of Health and Family Welfare, Govt. of India. He hosted the ASICON 2006 at Varanasi as Organizing Secretary. He has been a member of 12 national and international professional bodies and has published 470 papers in International and National Journals.

Dr. Manoj Pandey is a Professor in the Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi and Visiting Professor of the Department of Surgical Oncology, AIIMS, Rishikesh, Uttrakhand. He has served as the Director of Bhopal Memorial Hospital and Research Centre and National Institute for Research in Environmental Health, Indian Council of Medical Research. His research publications reflect his expertise in gallbladder cancer research and his aspiration for quality research. He has published more than 328 publications. He has been honored with several awards, including Dr. U C Gupta Memorial Award for Excellence in Surgery. Dr. Pandey has also been a member of the task force of ICMR on the review of cancer management.

Dr. Ruhi Dixit works as a Women Scientist in the Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. She has a keen interest in cancer research and has been working on gallbladder cancer. She has published in various journals of international reputation. Moreover, she has served as a reviewer of a reputed double-blind referred international journal. To perform cutting-edge research, she has also participated in various hands-on trainings and workshops in related areas and has presented her novel findings on reputed international platforms. She is currently working on the development of diagnostic biomarkers for gallbladder cancer.