Fusion Oncogenes & Acute Lymphoblastic Leukemia in Adults

ISBN-13: 9783659776588 / Angielski / Miękka / 2015 / 140 str.

Sabir Noreen

Opis

Chromosomal abnormalities play an important role in genesis of Acute Lymphoblastic Leukemia and have prognostic implications. This work is aimed at detecting common chromosomal translocation and associated fusion oncogenes in adult ALL patients and their relationship with clinical features and treatment outcome by using RT-PCR and interphase FISH. Five most common fusion oncogenes i.e. BCR-ABL, ETV6-RUNX1, MLL-AF4, SIL-TAL1 and TCF3-PBX1, were found in 79 percent of the patients in the sample. BCR-ABL and MLL-AF4 characterized a subset of adult ALL patients with aggressive clinical behavior and a poor outcome. Survival in ETV6-RUNX1 was better while SIL-TAL1 had frequent organomegaly and usually showed up with a platelets count less than 50x109/l. TCF3-PBX1 fusion oncogene was associated with lymphadenopathy. This is the first comprehensive study from Pakistan which investigates the frequency of fusion oncogenes, their association with clinical features, treatment response and outcome. This information will help in the prognostic stratification and risk adapted management of adult ALL patients in under developed countries like Pakistan.

O autorze

Dr Noreen Sabir was born and raised in Lahore, Pakistan where her passion for research and learning has led her from trekking difficult terrain in the Northern Areas of Pakistan while collecting fossils for her Geology research to collecting blood samples from cancer patients. She is a mother of four and wants to keep learning all her life.