Frontiers of Cord Blood Science

ISBN-13: 9781849967426 / Angielski / Miękka / 2010 / 400 str.

Niranjan Bhattacharya; Phillip Stubblefield

Opis

Cord blood is a significant source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Cord blood is also an alternative to embryos as a source of tissue for regenerative medicine. Cells from cord blood have been shown to transdifferentiate into nonhematopoietic cells, including those of the brain, heart, liver, pancreas, bone, and cartilage, in tissue culture and in animal systems. Recently it has been demonstrated that both cardiac and glial cell differentiation of cord blood donor cells occurred in recipients of unrelated donor cord blood transplantation as part of a treatment regime for Krabbe disease and Sanfilippo syndrome. These observations raise the possibility that cord blood may serve as a source of cells to facilitate tissue repair and regeneration in the future. CD34 stem cell-rich umbilical cord whole blood transfusion has the potential to have an immediate benefit of better tissue oxygenation with an additional delayed benefit of possible engraftment of umbilical cord stem cells.

Recenzje

From the reviews:

"The editors and authors of this book not only address current clinical science and banking of umbilical-cord blood, but also advance new concepts in medical therapeutics that use umbilical-cord blood. ... This book provides a clear summary of work that provides clues to the unique molecular and cellular biology of stem cells ... . The editors of this book ... making Frontiers of Cord Blood Science a valuable reference for researchers and clinicians who are interested in the evolving field of cellular therapies." (Mary J. Laughlin, New England Journal of Medicine, Vol. 361 (3), July, 2009)

"Studies with cord blood present a new field of science. It is a source of hematopoietic progenitor and stem cells, and enables investigation in genetics, immunology, etc. The book also explores possible future uses for stem cell transplantation and other therapeutic applications. A timely text." (Pediatric Endocrinology Reviews, Vol. 7 (3), March-April, 2010)

"The contens of this book are extremely important for ... the field of transplantation of umbilical cord blood stem cells. ... The extensiveness of the topics covered makes it a useful guide for specialists in this sector. ... text shall be responsible for spreading the knowledge acquired to date and, therefore, for inducing researchers to explore all possible fields of future applications ... . text to be of high scientific importance and are certain it will lead to further progress in clinical research and application." (Clinical and Experimental Obstetrics and Gynecology, Vol. XXXVII (3), 2010)

Spis treści

Umbilical Cord Blood Stem Cell (Basic Science).- Placental and Pregnancy Stem Cells.- Cord Blood Stem Cells – The Basic Science.- Stem Cells from Umbilical Cord Blood.- Ex Vivo Expansion of Cord Blood.- Mesenchymal Stem Cells: Applications in Cell and Gene Therapy.- Non-hematopoietic Stem and Progenitor Cells Derived From Human Umbilical Cord Blood.- Umbilical Cord Blood Stem Cell Transplantation.- Cord Blood Transplantation for Pediatric Non-Malignant Conditions.- Cord Blood Transplantation for Hematologic Malignancies.- Double Umbilical Cord Blood Transplantation in Adults.- Transfusion of Cord Blood.- Placental Umbilical Cord Whole Blood Transfusion: A True Blood Substitute to Combat Anemia in the Background of Chronic Disease – A Study Report (1999–2006).- Umbilical Cord Blood Therapy in Neurology.- Cord Blood: Opportunities and Challenges for the Reconstructive Surgeon.- Umbilical Cord Blood Transfusion – A Clinical Overview.- Cord Blood Stem Cell Banking.- Establishment of the UK Stem Cell Bank and Its Role in Stem Cell Science.- Cord Blood Allogeneic and Autologous Banking.- Potential Engineering Application of Cord Blood.- Possibilities of Using Cord Blood for Improving the Biocompatibility of Implants.- Potential of Stem Cell to Tailor the Bone-Ceramic Interface for Better Fixation of Orthopedic Implants.- Ethics.- Some Aspects of the Ethics of Stem Cell Research.

Blurb

Since the first successful transplantation of umbilical cord blood in 1988, cord blood has become an important source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Significant progress has been accompanied by challenges for scientists, ethicists, and health policy makers. With the recognition of the need for a national system for the collection, banking, distribution, and use of cord blood and the increasing focus on cord blood as an alternative to embryos as a source of tissue for regenerative medicine, it has garnered significant attention recently.

Frontiers in Cord Blood Science contains chapters from distinguished investigators currently engaged in researching cord blood in the treatment of various diseases of the brain, heart, liver, pancreas, bone and cartilage. The current state of research in the field is presented and the potential future applications of cord blood both for research and for the treatment of different diseases and conditions is discussed. In addition, the book reviews the possibility for novel uses in surgical wound healing and in synthetic grafts for reconstructive surgery, allowing their better adhesion.

Investigating the ethical issues, this book will be of interest to all scientists and researchers within the field of regenerative medicine and also clinicians in dermatology, neurology, cardiology and orthopedics wishing to discover more about the potential for the revolutionary medical approach of human umbilical cord blood.