Frontiers in Biochip Technology

ISBN-13: 9780387255682 / Angielski / Twarda / 2006 / 358 str.

WAN-Li Xing; Jing Cheng

Opis

Frontiers in Biochip Technology
Dr. Wan-Li Xing and Dr. Jing Cheng

Frontiers in Biochip Technology serves as an essential collection of new research in the field of biochip technology. This comprehensive collection covers emerging technologies and cutting -edge research in the field of biochip technology, with all chapters written by the international stars of this evolving field.

Key topics and current trends in biochip technology covered include:

-microarray technology and its applications

- microfluidics

- drug discovery

- detection technology

- lab-on-chip technology and bioinformatics.

Frontiers in Biochip Technology is an important volume for all biotechnologists, bioengineers, genetic engineers, pharmacological researchers, and general bench researchers who want to be up-to-date on the latest advances in the rapidly growing field of biochip technology.

The Editors:

Dr. Wan-Li Xing, Tsinghua University School of Medicine, National Engineering Research Center for Beijing Biochip Technology (NERCBBT), and CapitalBio Corporation, Beijing, China
Dr. Xing is a Professor at Medical Systems Biology Research Center, Tsinghua University School of Medicine, and also serves as the Executive Deputy Director at NERCBBT, CapitalBio Corporation, a world-leader in biochip research. Dr. Xing has published widely and obtained many patents and applications.

Dr. Jing Cheng, Tsinghua University School of Medicine, National Engineering Research Center for Beijing Biochip Technology (NERCBBT), and CapitalBio Corporation, Beijing, China
Dr. Jing Cheng is the Cheung Kong Professor at Medical Systems Biology Research Center, Tsinghua University School of Medicine, the Director of NERCBBT and CEO & CTO of CapitalBio. Dr. Cheng developed the world's first system of laboratory-on-a-chip in 1998; this work was featured in the front-cover story of the June 1998 issue of Nature Biotechnology and cited as the breakthrough of the year by Science in the same year. He has been awarded Nanogen's most prestigious award Nano Grant, Distinguished Achievement Award for Overseas Chinese Scholars Returned, China's Science & Technology Award for Outstanding Youth, and Qiushi Technology Transfer Award for Outstanding Youth. Dr. Cheng has published over 90 peer-reviewed papers. In addition, he has obtained over 60 European and U.S. patents and applications.

Spis treści

Microarrays.- A Homogenous Microarray for Enzymatic Functional Assays.- Improvement of Microarray Technologies for Detecting Single Nucleotide Mismatch.- Miniaturized Multiplexed Protein Binding Assays.- MEA-Based Spike Recording in Cultured Neuronal Networks.- Cell-Transistor Hybrid Systems.- Microfluidics and Lab-on-a-Chip.- Microfabricated Chip Electrophoresis Technology for DNA Analysis.- Microfabrication and Application of Recessed Gold Electrodes in Microchip Electrophoresis System.- Fast Screening of Single-Nucleotide Polymorphisms Using Chip-Based Temperature Gradient Capillary Electrophoresis.- Electro-Osmotic Flow Micro Pumps for Cell Positioning in Biochips.- Surface Chemistry.- The Application of Novel Multi-Functional Microarray Slides for Immobilization Biomolecules.- Novel Surface Technologies for Genomics, Proteomics, and Drug Discovery.- Photoactivatable Silanes: Synthesis and Uses in Biopolymer Array Fabrication on Glass Substrates.- Bioinformatics and Drug Discovery.- An Integrated Biochemoinformatics System for Drug Discovery.- New Technologies.- Development of the MGX 4D Array System Utilizing Flow-Thru Chip Technology.- Sequencing by Aligning Mutated DNA Fragments (SAM).- Fabrication of Double-Stranded DNA Microarray on Solid Surface for Studying DNA-Protein Interactions.- Electronic Biosensors Based on DNA Self-Assembled Monolayer on Gold Electrodes.- Applications.- Multi-Parameter Read-Out in Miniaturized Format.- Evaluation of the Reliability of cDNA Microarray Technique.- High-Throughput Tissue Microarray Technology for the Rapid Clinical Translation of Genomic Discoveries.