Freeze Drying of Pharmaceutical Products

ISBN-13: 9780367076801 / Angielski / Twarda / 2019 / 192 str.

Davide Fissore; Roberto Pisano; Antonello Barresi

Opis

This book provides an overview of the most recent and cutting-edge developments and technologies in the field, focusing on formulation developments and process monitoring, and considering new technologies for process development.

Spis treści

1. The Freeze-Drying of Pharmaceutical Products: Introduction and Basic Concepts

[Davide Fissore, Roberto Pisano, and Antonello Barresi]

2. Formulation Design and Optimization Using Molecular Dynamics

[Roberto Pisano and Andrea Arsiccio]

3. Established and Novel Excipients for Freeze-Drying of Proteins

[Ivonne Seifert and Wolfgang Friess]

4. Infrared Imaging and Multivariate Image Analysis (MIA): A New PAT for Freeze-Drying Monitoring and Control

[Domenico Colucci, José Manuel Prats-Montalbán, Alberto Ferrer, and Davide Fissore]

5. Through-Vial Impedance Spectroscopy (TVIS): A New Method for Determining the Ice Nucleation Temperature and the Solidification End Point

[Geoff Smith and Yowwares Jeeraruangrattana]

6. Innovations in Freeze-Drying Control and In-Line Optimization

[Antonello Barresi, Roberto Pisano, and Davide Fissore]

7. Use of a Micro Freeze-Dryer for Developing a Freeze-Drying Process

[Taylor N. Thompson and Davide Fissore]

8. Continuous Manufacturing in Lyophilization of Pharmaceuticals: Drawbacks of Batch Processing, Current Status, and Perspectives

[Roberto Pisano, Luigi C. Capozzi, and Jos A.W.M. Corver]

9. Use of CFD for the Design and Optimization of Freeze-Dryers

[Antonello Barresi]