Free Radicals and the Liver

ISBN-13: 9783642768767 / Angielski / Miękka / 2011 / 157 str.

Geza Csomos; Janos Feher; E. Albano

Opis

Based on the results of the latest congress of the European Association for the Study of the Liver (EASL), this volume makes excellent reading since it explores in detail the role of free radical reactions in liver diseases. Studies in recent years using various methods have shown that free radicals play an important role in toxic liver disorders. For this reason, the current scientific knowledge is presented in this balanced, clinical portrayal. The account refers to the many observations, experiencesand evaluations that have been made both clinically and experimentally. Two major areas discussed concern the pathophysiological changes by free radicals and the therapeutic possibilities that have come to light.

Spis treści

Role of Free Radical Reactions in Liver Diseases.- Oxidative Stress in Chemical Toxicity.- Relationships Between Free Radical Reactions and the Function of the Cytochrome P-450 System.- Regulation Mechanisms of Xenobiotics Metabolizing Liver Cytochrome P-450 and Toxicological Implications.- Lipid Peroxidation and Hepatocyte Damage in the Animal Model and in Human Patients.- Calcium, Phospholipase A2, and Eicosanoids in Toxigenic Liver Cell Injury.- Lipid Peroxidation and Associated Hepatic Organelle Dysfunction in Iron Overload.- Structural Principles of Flavonoid Antioxidants.- Role of Free Radical Reactions in Experimental Hyperlipidemia in the Pathomechanism of Fatty Liver.- Free Radical Reactions in the Pathomechanism of Amiodarone Liver Toxicity.