Frailty and Sarcopenia in Cirrhosis: The Basics, the Challenges, and the Future

ISBN-13: 9783030262280 / Angielski / Miękka / 2020 / 279 str.

Puneeta Tandon; Aldo J. Montano-Loza

Spis treści

I The Basics

1 Definition & Diagnosis of Sarcopenia in the Research and Clinical Settings

Aldo J. Montano-Loza, Maryam Ebadi

 

2 The Definition and Diagnosis of Frailty in the Research and Clinical Settings

Hui-Wei Chen, Andres Duarte-Rojo

3 Deciphering the Cirrhotic Patient’s Present Status: The Overlap between Physical Frailty, Disability and Sarcopenia

Elliot B. Tapper 

4 The Pathogenesis of Physical Frailty and Sarcopenia

Srinivasan Dasarathy 

5 Prognostic Implications of Physical Frailty and Sarcopenia Pre and Post Transplantation

Stefan Buettner, Jan N.M. IJzermans, Jeroen L.A. van Vugt

6 Nutritional Therapy in the Management of Physical Frailty and Sarcopenia

Manuela Merli, Barbara Lattanzi, Daria D’Ambrosio, Nicoletta Fabrini, Alice Liguori

7 Exercise Training in Patients with Cirrhosis

Graeme M. Purdy, Kenneth J. Riess, Kathleen P. Ismond, Puneeta Tandon 

II The Challenges

8 Sex, Age and Ethnicity Dependent Variation in Body Composition: Can There Be a Single Cut-off?

Maria Cristina Gonzalez, Jingjie Xiao, Ilana Roitman Disi

9 Muscle Mass versus Muscle Strength and Performance: Is Muscle Mass Measurement Alone Enough?

Matthew Kappus, Pranab Barman

10 The Role of Changes in Subcutaneous and Visceral Adiposity, Sarcopenic Obesity and Myosteatosis/Muscle Quality in Cirrhosis: How to Diagnose It and Its Contribution to Prognosis

Maryam Ebadi, Aldo J. Montano-Loza

11 Evidence for the Assessment of Physical Frailty and Sarcopenia in Hospitalized Patients and the Role of Assessing Changes Over Time

Guido Stirnimann

12 Frailty and Sarcopenia in the Selection of Candidates for Liver Transplantation

Christopher J. Sonnenday

13 Physical Frailty and Sarcopenia in End Stage Liver Disease: Do They Improve after Liver Transplantation?

Rahima A. Bhanji, Elizabeth J. Carey

14 Measures of Sarcopenia: The Utility of Ultrasound, Bioelectrical Impedance Analysis, and Single-Slice Cross-Sectional Imaging 

Marina Mourtzakis, Kirsten Elizabeth Bell

III The Future

15 Upcoming Pharmacological and Interventional Therapies for the Treatment of Physical Frailty and Sarcopenia

Penelope Hey, Marie Sinclair

16 Should Frailty Include Multidimensional and Dynamic Factors?

Darryl B. Rolfson

17 Hepatic Encephalopathy, Sarcopenia and Frailty

Chantal Bémeur, Christopher F. Rose

18 A Research Wish List to Understand, Diagnose and Manage Frailty and Sarcopenia

Michael A. Dunn

O autorze

Puneeta Tandon, MD

University of Alberta

Department of Medicine

Division of Gastroenterology and Liver Unit

Edmonton, Alberta 

Canada

Aldo J. Montano-Loza, MD

University of Alberta

Department of Medicine

Division of Gastroenterology and Liver Unit

Edmonton, Alberta

Canada

Blurb

This book provides a concise yet comprehensive overview of frailty and sarcopenia in the cirrhotic patient. The text presents a personalized approach to identifying cirrhotic patients at risk of higher morbidity and mortality due to frailty and sarcopenia. It reviews current and novel diagnostic methods, while spotlighting treatment and management strategies for frailty and sarcopenia. The book also focuses on special issues associated with these syndromes, such as the effect of gender, age, and ethnicity on frailty and sarcopenia, sarcopenic obesity, and frailty and sarcopenia after liver transplantation. Future considerations are outlined in the closing chapters, including emerging pharmacological and interventional therapies for these syndromes.

Written by experts in the field, Frailty and Sarcopenia in Cirrhosis: The Basics, the Challenges, and the Future is a valuable resource for clinicians and practitioners who treat patients with cirrhosis.