Kar, Nihar RanjanThis is my project work of Master in Pharmacy in Pharmaceutics in Gayatri college of Pharmacy,Sambalpur,Odisha,India.My research guide was Prof.(Dr.)Santosh Kumar Mahapatra,Principal that time and Senior Lecturer in pharmaceutics Mr. rajesh Kumar Pothal.It is my dedicated work to obtain the final project which was helped by other collegues also.