Formulation and Evaluation of Fast Dissolving Film of Chlorpromazine

ISBN-13: 9786202524209 / Angielski / Miękka / 2020 / 116 str.

Vinay Pandit; Priyanka Sharma; M. S. Ashawat

Opis

Emesis is the involuntary and forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose. Receptors on the floor of the ventricle of the brain represent a chemo-receptor trigger zone, known as the area postrema, stimulation of which can lead to vomiting. Chlorpromazine HCl is formulated as a sublingual film. The films formed by HPMC K-15 at a concentration of 120 mg showed the desirable character for a sublingual film. The optimized films formed were subjected to evaluation parameters viz. Tensile Strength, Disintegration, In-vitro dissolution, Ex-vivo Permeation studies and In-vivo studies and the results complied with the available statistical data. In-vitro dissolution studies were analyzed and Higuchi model was found to be the best fit model for In-vitro dissolution studies with a regression value of 0.9248. Ex-vivo permeation studies showed fivefold enhanced permeation of drug from films as compared to pure drug. In conclusion, a sublingual film of Chlorpromazine HCl may result in better patient compliance, quick onset of action and enhanced bio-availability.

O autorze

Pandit, Vinay
Dr. Vinay Pandit is working as a Professor and Head, Department of Pharmaceutics, Laureate Institute of Pharmacy. His current area of research is a Novel drug delivery system and fast dissolving technology. He has a number of publications in reputed national and international journals.