Fibrosis in Disease: An Organ-Based Guide to Disease Pathophysiology and Therapeutic Considerations

ISBN-13: 9783319981420 / Angielski / Twarda / 2018 / 471 str.

Monte Willis; Cecelia C. Yates; Jonathan C. Schisler

Opis

Fibroproliferative diseases are a broad spectrum of entities from organ-specific involvement (e.g., pulmonary, heart, liver, and kidney fibrosis) to multi-system diseases such as systemic sclerosis and sclerodermatous graft vs.

Spis treści

Introduction.- The Role of Chemokines in Fibrotic dermal remodeling and wound healing.- Fibrosis and immune dysregulation in systemic sclerosis.- Macrophage Plasticity in Skin Fibrosis.- Fibrotic Signaling in the Lung.- Pulmonary Matrikines: Origin, Function and Contribution to Fibrotic and Non-Fibrotic Lung Disease.- The Role of Mast Cells in the Pathophysiology of Pulmonary Fibrosis.- PERICYTES AND T CELLS IN LUNG INJURY AND FIBROPROLIFERATION.- Emerging Therapeutic Targets and Therapies in Idiopathic Pulmonary Fibrosis.- Dynamic reciprocity- the role of the extracellular matrix microenvironment in amplifying and sustaining pathological lung fibrosis.- Fibrotic Signaling in Cardiomyopathies.- WNT SIGNALING AND CARDIAC FIBROSIS.- Matrix metalloproteinase-9-dependent mechanisms of reduced contractility and increased stiffness in the aging heart.- Using peptidomics to identify extracellular matrix-derived peptides as novel therapeutics for cardiac disease.- Vascular Fibrosis and Disease.- Liver Fibrosis: Current Approaches and Future Directions for Diagnosis and Treatment.- Tipping the balance from angiogenesis to fibrosis in chronic kidney disease.- Fibrotic Remodeling in Exudative (Wet) Macular Degeneration.

O autorze

Monte S. Willis
Indiana University School of Medicine
Indiana Center for Musculoskeletal Health
Department of Pathology & Laboratory Medicine
Krannert Institute of Cardiology
Indianapolis, IN
USA

Cecelia C. Yates
University of Pittsburgh
School of Nursing
Pittsburgh, PA
USA 

Jonathan C. Schisler
University of North Carolina
McAllister Heart Institute
Department of Pharmacology
Department of Pathology and Lab Medicine
Chapel Hill, NC
USA

Blurb

This book serves as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of fibroproliferative diseases. It provides new insight into the fundamental mechanisms of classic fibrotic pathophysiologic processes like myocardial infarction, idiopathic pulmonary fibrosis, chronic kidney disease, wound healing, and systemic sclerosis. It also highlights the many new areas of therapeutic investigation currently underway. Lastly, it touches upon newly emerging fields and investigates the role of fibrosis in macular degeneration and cancer metastasis.

Chapters are written by established experts in their fields, including clinicians, cardiologists, cardiovascular surgeons, pathologists, general practitioners, and translational biomedical researchers in a wide range of disciplines. However, the material also applies to a broader audience, including medical residents, fellows, and M.D. or Ph.D. post-doctoral research fellows. While comprehensive, this book presents the material in a manner that simplifies the complex pathophysiologic mechanisms that underlie common fibroproliferative diseases while making it appealing to a broad audience.