Fetal Stem Cells in Regenerative Medicine: Principles and Translational Strategies

ISBN-13: 9781493934812 / Angielski / Twarda / 2016 / 453 str.

Dario Fauza; Mahmud Bani

Opis

This book explores the regenerative properties of fetal stem cells, from feto-maternal cell traffic through perinatal stem cells, with a discussion of key topics including stem cell banking, drug screening, in utero stem cell transplantation and ethical considerations. The expertly authored chapters also delve into embryonic, amniotic membrane, and umbilical cord blood stem cells; fetal development models; fetal cell reprogramming; culture methods; disease models; perinatal gene therapy, and more. These chapters are grouped into four sections, each discussing a separate prenatal stem cell population and providing fascinating historical contexts for our knowledge of these systems.

Featuring a foreword written by the renowned Dr. Joseph Vacanti of the Harvard Stem Cell Institute, Fetal Stem Cells in Regenerative Medicine: Principles and Translational Strategies is a welcome and timely contribution to the Stem Cell Biology and Regenerative Medicine series. It is essential reading for scientists and researchers, clinicians and residents, and advanced students involved in stem cells, regenerative medicine, tissue engineering, and related disciplines such as embryology.

Spis treści

1 Historical Perspectives.- 2 Feto-Maternal Cell Traffic and Labor.- 3 Paracrine Effects of Fetal Stem Cells.- 4 Immunogenicity and Immunomodulation of Fetal Stem Cells.- 5 Embryonic Stem Cells and Fetal Development Models.- 6 Fetal Cell Reprogramming.- 7 Historical Perspectives.- 8 Amniotic Membrane Stem Cell Populations.- 9 Amniotic Fluid Stem Cell Populations.- 10 Amniotic Fluid Stem Cell Culture Methods.- 11 MicroRNA expression in Amniotic Fluid Cells.- 12 Historical Perspectives.- 13 Umbilical Cord Blood Stem Cell Populations.- 14 Wharton’s Jelly Stem Cells.- 15 Placental Stem Cells and Culture Methods.- 16 Fetal Stem Cell Banking.- 17 In Utero Stem Cell Transplantation.- 18 Fetal Tissue Engineering.- 19 Perinatal Gene Therapy.- 20 Transamniotic Stem Cell Therapy (TRASCET).- 21 Stem Cells and Commercialization.                        

O autorze

Dr. Dario Fauza received his M.D. from the University of São Paulo Medical School, in São Paulo, Brazil, where he also received a PhD-equivalent degree. While at the University’s Hospital of Clinics, he completed an internship and residencies in both general and pediatric surgery. He then moved to the United States, where he completed different clinical and research fellowships, as well as postdoctoral training, at Boston Children's Hospital in Boston, Massachusetts. He has an extensive bibliography as well as a patent portfolio. His research is directed at developing original, more effective ways to repair birth defects, both pre- and post-natally. To that end, he has pioneered and explored a variety of approaches, including fetal tissue engineering.

Dr. Mahmud Bani received his Ph.D. in neurodevelopment from the Department of Anatomy and Cell Biology at the University of Western Ontario in Ontario, Canada. He completed an NSERC postdoctoral fellowship in the Neural Stem Cell Laboratory at Robarts Research Institute in Ontario, Canada. He is currently a senior research officer in the Department of Translational Biosciences at the National Research Council Canada in Ottawa, Canada, and an adjunct professor in the Department of Cellular and Molecular Medicine at the University of Ottawa in Ottawa, Canada. Dr. Bani's ongoing research is to better understand the cellular and molecular mechanisms of neurogenesis and to develop neuroprotection and neuroregeneration strategies for the injured brain.