Fatal Attractions: Protein Aggregates in Neurodegenerative Disorders

ISBN-13: 9783642086496 / Angielski / Miękka / 2010 / 140 str.

V. M. -Y Lee; J. Q. Trojanowski; L. Buee

Opis

In this volume are contributions based on a meeting arranged by the WHO and the Fondation IPSEN. The scientists focus on neurodegenerative disorders like Alzheimer's Disease, Chromosome 17-Linked Dementia, Parkinson's Disease and disorders with tauopathies.

Spis treści

The Role of alpha-Synuclein in Parkinsons Disease: A Biophysical Analogy to Abeta and Alzheimers Disease.-Purification of Lewy Bodies and Identification of alpha-Synuclein as a Major Component of Lewy Bodies.-Mutational Analysis of Tau in Chromosome 17-Linked Dementia.-Missense and Splice Site Mutations in Tau Associated with FTDP-17: Multiple Pathogenic Mechanisms.-Tau Mutations: Genetics and Pathogenetic Mechanisms.-Tauopathies and alpha -Synucleinopathies.-Distinct Tau Gene Mutations Induce Specific Dysfunctions/Toxic Properties in Tau Proteins Associated with Specific FTDP-17 Phenotypes.-Neurodegenerative Disorders with Tauopathies: Mad Tau Diseases?.-Tau Protein: Role in Intracellular Traffic and Development of Cell Polarity.-Subject Index