Expression Profiling of Human Tumors: Diagnostic and Research Applications

ISBN-13: 9781617373756 / Angielski / Miękka / 2010 / 399 str.

Marc Ladanyi; William L. Gerald

Opis

A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. A primer on the technology and its novel analytical methods. Contains over 40 color images. Explains both the theory and practice of comprehensive gene expression profiling. Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications offers every oncologist, pathologists, and cancer surgeons an essential introduction to the most promising new high-throughput investigative approaches in molecular biology-technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.

Recenzje

"This timely and topical book provides cancer researchers, oncologists, pathologists and cancer surgeons with an essential introduction to the most promising high-throughput investigative approach in molecular biology today...." (biotech-online.com)

"...written clearly and in great detail with excellent often colorful illustrations which make them very easy to follow and very understandable...a major contribution to the field of expression profiling of human tumors for both these in the fields as well as those wanting to learn about this technique and its applications." (Medical Oncology)

Spis treści

Part I. Introduction Introduction: Present and Potential Impact of Expression Profiling Studies of Human Tumors Marc Ladanyi and William L. Gerald Part II. Technical Aspects cDNA Microarrays Paul S. Meltzer Oligonucleotide Microarrays Marina Chicurel and Dennise Dalma-Weiszhausz Serial Analysis of Gene Expression (SAGE) in Cancer Research C. Marcelo Aldaz Tissue Arrays Cyrus V. Hedvat Microarray Data Analysis: Cancer Genomics and Molecular Pattern Recognition Pablo Tamayo and Sridhar Ramaswamy The Role of Tumor Banking and Related Informatics Stephen J. Qualman, Jay Bowen, Sandra Brewer-Swartz, and Mary France Part III. Applications Characterization of Gene Expression Patterns for Classification of Breast Carcinomas Irene L. Andrulis, Nalan Gokgoz, and Shelley B. Bull Microarray Analysis of Colorectal Cancer Daniel A. Notterman, Carrie J. Shawber, and Wei Liu Gene Expression Analysis of Prostate Carcinoma William L. Gerald Classification of Human Lung Carcinomas by mRNA Expression Profiling Arindam Bhattacharjee and Matthew Meyerson Molecular Profiling of Bladder Cancer Using High-Throughput DNA Microarrays Marta Sánchez-Carbayo and Carlos Cordon-Cardo Gene Expression Profiling of Renal Cell Carcinoma and its Clinical Implications Masayuki Takahashi and Bin Tean Teh Expression Profiling of Pancreatic Ductal Adenocarcinoma Christine A. Iacobuzio-Donahue and Ralph H. Hruban Gene Expression in Ovarian Carcinoma Garret M. Hampton Classification of Pediatric Tumors Using DNA Microarrays Javed Khan and Marc Ladanyi Transcriptomes of Soft Tissue Tumors: Pathologic and Clinical Implications Sabine C. Linn, Rob B. West, and Matt van de Rijn Gene Expression Profiling inLymphoid Malignancies Wing C. Chan and Louis M. Staudt Gene Expression Profiling of Brain Tumors Meena K. Tanwar and Eric C. Holland Expression Profiling of Bone Tumors Deborah Schofield, Daniel Wai, and Timothy J. Triche Index

Blurb

Global gene expression profiling is a new and comprehensive approach to the investigation of tumor biology that has the potential to sharply alter the future of cancer research, diagnostic pathology, and clinical oncology. In Expression Profiling of Human Tumors: Diagnostic and Research Applications, over 20 leading investigators offer the first thorough review of the application of this novel technology to human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. For each cancer type, the authors assess the potential of the approach in reaching more precise diagnoses, as well as in the identification of prognostic markers, therapeutic targets, and gene expression patterns that accurately predict therapeutic response. A section on the technology and its novel analytical methods explains both the theory and practice of comprehensive gene expression profiling
Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications provides every cancer researcher, oncologist, pathologist, and cancer surgeon an essential introduction to the most promising high-throughput investigative approach in molecular biology today-a technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.