Experimental Models of Cardiovascular Diseases: Methods and Protocols

ISBN-13: 9781493993383 / Angielski / Miękka / 2019 / 404 str.

Kiyotake Ishikawa

Spis treści

Part I: Overview

 

1.                  Experimental Models of Cardiovascular Diseases - Overview -

Jae Gyun Oh and Kiyotake Ishikawa

 

Part II :In Silico Models

2.                  An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity

Joshua Mayourian, Eric A. Sobie, and Kevin D. Costa

 

Part III: In Vitro Models

3.                  Isolation of Atrial and Ventricular Cardiomyocytes for In Vitro Studies

Jelena Plačkić and Jens Kockskämper

 

4.                  Cardiomyocyte Differentiation from mouse Embryonic Stem Cells 

Adam T Lynch, Silvia Mazzotta, and Stefan Hoppler

 

5.                  Cardiomyocyte Differentiation from Human Embryonic Stem Cells 

Silvia Mazzotta, Adam T Lynch, and Stefan Hoppler

 

6.                  Induction of Human Induced Pluripotent Stem Cells to Cardiomyocytes using Embryoid Bodies

Takeshi Hatani1, Kenji Miki, and Yoshinori Yoshida

 

7.                  Measuring Cardiomyocyte Contractility and Calcium Handling In Vitro

Przemek A. Gorski, Changwon Kho, and Jae Gyun Oh

 

Part IV: Ex Vivo Models

 

8.                  Langendorff Perfusion Method as an Ex Vivo Model to Evaluate Heart Function in Rats

Makino Watanabe and Takao Okada

 

9.                  Methods for the Preparation of an Excised, Cross-circulated Rat Heart

Koji Obata and Miyako Takaki

 

10.              Optical Action Potential Mapping in Acute Models of Ischemia-reperfusion Injury: Probing the Arrhythmogenic Role of the Mitochondrial Translocator Protein

Zeki Ilkan, Benjamin Strauss, Chiara Campana, and Fadi G. Akar

 

11.              Cardiac Tissue Engineering Models of Inherited and Acquired Cardiomyopathies

Irene C. Turnbull, Joshua Mayourian, Jack F. Murphy, Francesca Stillitano,

Delaine K. Ceholski, and Kevin D. Costa

 

12.              Badimon Perfusion Chamber: An Ex Vivo Model of Thrombosis

M. Urooj Zafar, Carlos G. Santos-Gallego, Lina Badimon, and Juan J. Badimon,

Part V: Small Animal Models

13.              Ischemic Model of Heart Failure in Rats and Mice

Jiqiu Chen, Delaine K. Ceholski, Irene C. Turnbull, Lifan Liang, and Roger J. Hajjar

 

14.              Conventional Method of Transverse Aortic Constriction in Mice

Jimeen Yoo, Vadim Chepurko, Roger J. Hajjar, and Dongtak Jeong

 

15.              Characterization of the Differential Progression of Left Ventricular Remodeling in a Rat Model of Pressure Overload Induced Heart Failure. Does Clip Size Matter?

Antoine H. Chaanine and Roger J. Hajjar

 

16.              Isoproterenol-induced Heart Failure Mouse Model Using Osmotic Pump Implantation

Sunny C. Chang, Shuxun Ren, Christoph D. Rau, and Jessica J. Wang

 

17.              Rat model of Cardiotoxic Drug Induced Cardiomyopathy

Takehiro Nakahara, Takashi Tanimoto, Artiom D. Petrov, Kiyotake Ishikawa,  H. William Strauss, and Jagat Narula

 

18.              Pulmonary Artery Hypertension Model in Rats by Monocrotaline Administration

Carlos Bueno-Beti, Yassine Sassi, Roger J. Hajjar, and Lahouaria Hadri

 

19.              The Sugen 5416/Hypoxia Mouse Model of Pulmonary Arterial Hypertension

Carlos Bueno-Beti, Lahouaria Hadri, Roger J. Hajjar, and Yassine Sassi

 

20.              Mouse Model of Wire Injury-Induced Vascular Remodeling

Aya Nomura-Kitabayashi and Jason C. Kovacic

 

21.              The Mouse Aortocaval Fistula Model with Intraluminal Drug Delivery

Toshihiko Isaji and Alan Dardik

 

 

Part VI: Large Animal Models

22.              A Pig Model Of Myocardial Infarction: Catheter Based Approaches

Olympia Bikou, Shin Watanabe, Roger J. Hajjar, and Kiyotake Ishikawa

 

23.              Ovine Model of Ischemic Mitral Regurgitation

Dae-Hee Kim, Morris Brittan, J. Luis Guerrero, Suzanne M. Sullivan, Judy Hung, and Robert A. Levine

 

24.              Canine Model of Pacing-induced Heart Failure

Jeffery C. Powers and Fabio Recchia

 

25.              Swine Model of Mitral Regurgitation Induced Heart Failure

Shin Watanabe, Olympia Bikou, Roger J. Hajjar and Kiyotake Ishikawa

 

26.              Pig Model of Increased Cardiac Afterload Induced by Ascending Aortic Banding

Olympia Bikou, Satoshi Miyashita, and Kiyotake Ishikawa

 

27.              Large Porcine Model of Profound Acute Ischemic Cardiogenic Shock

Ole K. Møller-Helgestad, Hanne B. Ravn, and Jacob E. Møller

 

28.              Chronic Pulmonary Artery Embolization Models in Large Animals

Jaume Aguero, Nadjib Hammoudi, Olympia Bikou, Kenneth M. Fish, Iratxe Zarragoikoetxea, Roger J. Hajjar, and Kiyotake Ishikawa

 

29.              Modeling Pulmonary Hypertension: A Pig Model Of Post-capillary Pulmonary Hypertension

Olympia Bikou, Kiyotake Ishikawa, Kenneth M. Fish, Iratxe Zarragoikoetxea, Roger J. Hajjar, and Jaume Aguero

 

30.              Development and Multiparametric Evaluation of Experimental Atherosclerosis in Rabbits

Max L. Senders, Mark E. Lobatto, Raphael Soler, Olivier Lairez, Carlos Pérez-Medina, Claudia Calcagno, Zahi A. Fayad, Willem J.M. Mulder, and Francois Fay

Blurb

T​his book provides methodological information on establishing reliable and reproducible experimental models of cardiovascular diseases. Chapters detail practical protocols from expert laboratories focusing on cardiovascular research, leading to novel discoveries in cardiac biology, and the development of effective therapeutic approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 Authoritative and cutting-edge, Experimental Models of Cardiovascular Disease: Methods and Protocols aims to ensure successful results in the further study of this vital field.