Experimental Models in Serotonin Transporter Research

ISBN-13: 9780521514873 / Angielski / Twarda / 2010 / 367 str.

Allan V Kalueff

Opis

The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron. This control over neuronal signalling makes it a prime area of neuroscientific study. In this book an international team of top experts introduce and explicate the role of serotonin and the serotonin transporter in both human and animal brains. They demonstrate the relevance of the transporter and indeed the serotonergic system to substrates of neuropsychiatric disorders, and explain how this knowledge is translated into valid animal models that will help foster new discoveries in human neurobiology. Writing for graduate students and academic researchers, they provide a comprehensive coverage of a wide spectrum of data from animal experimentation to clinical psychiatry, creating the only book exclusively dedicated to this exciting new avenue of brain research.

Recenzje

'… essential reading and reference material for any researcher working on neuroscience in the fields of medicine, psychology, pharmacology and developmental biology, particularly where animal models are being used to further understanding of human brain development and disorders. … Non-specialists interested in this field, and willing to grapple with some academically challenging reading will find material to both furnish increased understanding of the background to current research and stimulate them to further reading.' Pamela J. Speed, Journal of Biological Education

Spis treści

Preface: focus on serotonin transporter Allan V. Kalueff and Justin L. LaPorte; 1. Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake Beth A. Luellen, Tracy L. Gilman and Anne M. Andrews; 2. Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages Qian Li; 3. Developmental roles for the serotonin transporter Antonio M. Persico; 4. SERT models of emotional dysregulation Adam Tripp and Etienne Sibille; 5. The serotonin transporter and animal models of depression Daniela Popa, Chloé Alexandre, Joëlle Adrien and Clément Léna; 6. The serotonin transporter knockout rat: a review Jocelien Olivier, Alexander Cools, Bart Ellenbroek, Edwin Cuppen and Judith Homberg; 7. Wistar-Zagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter Lipa Cicin-Sain and Branimir Jernej; 8. The role of the serotonin transporter in reward mechanisms F. Scott Hall, Ichiro Sora, Maria T. G. Perona and George R. Uhl; 9. Modeling SERT x BDNF interactions in brain disorders: single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knockout mice Justin L. LaPorte, Renee F. Ren-Patterson, Dennis L. Murphy and Allan V. Kalueff; 10. Primate models in serotonin transporter research Khalisa N. Herman, James T. Winslow and Stephen J. Suomi; 11. The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain Klaus-Peter Lesch.