Evaluation of Antiulcer Activity of the Leaf of Osyris quadripartita

ISBN-13: 9783330025080 / Angielski / Miękka / 2016 / 104 str.

Bharat Mishra; Mastewal Abebaw; Badmanaban Ramalingam

Opis

Objective: To evaluate the antiulcer activity of the leaf extract of Osyris Quadripartita ( OQ) in albino wistar rats. Methods: The 80% methanolic extract of OQ leaves was subjected to acute toxicity test and phythochemical analysis. The extract's anti-ulcer activity were studied using the pylorus ligation and ethanol induced ulcer model both for dose dependent (100, 200, 400mg/kg) and time dependent (200mg/kg for 10 & 20 days) studies. Volume, pH, total acidity, ulcer score and ulcer index were determined for pylorus ligation induced ulcer model and ranitidine 50mg/kg (R50) was used as a standard dug. In ethanol induced ulcer model ulcer score and ulcer index were determined and sucralfate 100mg/kg (S100) was used as a standard drug. Conclusion: The 80% methanolic extract of OQ exhibited anti-ulcer activity which is comparable to the standard drugs and this could be attributed to the possible presence of one or more secondary metabolites. This supports the ethnomedicinal use of leaves of Osyris quadripartita.

O autorze

I am Dr.Bharat Mishra working as an Associate Professor and Head, Dept of Pharmacology Nirmala college of Pharmacy. Having 11 years of Teaching and Research experience.Published 20 Research Papers and a Fellow Member of Indian Chemical Society.Worked in university of Gondar,Ethiopia,Africa.Guided 05 M.Pharm Projects.Organised many conferences.